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Cat. No.: HY-144793

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Deac-SS-Biotin

Deac-SS-Biotin is a potent antitumor agent with improved tumor targeting effects and reduced off-target toxicities. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity.

For research use only. We do not sell to patients.

Formula: C₃₅H₄₅N₃O₁₀S₃
Molecular Weight:763.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Deac-SS-Biotin Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Deac-SS-Biotin (compound 9) (5 μM; 24 h) has a remarkable reduction-responsive drug release^[1].
Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin^[1].
Deac-SS-Biotin (5 μM, 5 μM and 10 μM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

SGC-7901, A549, Hela, L929 cells
Concentration:

0-20 µM
Incubation Time:

72 h
Result:

Showed potent antiproliferative activity with IC₅₀s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells, respectively.

Cell Viability Assay^[1]

Cell Line:

A549 cells
Concentration:

0.17 µM
Incubation Time:
Result:

Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.

Chemical Information

Molecular Weight 763.94
Formula C₃₅H₄₅N₃O₁₀S₃
SMILES

[H][C@]12NC(N[C@]1(CS[C@H]2CCCCC(OCCSSCCOC(N[C@H]3CCC4=C(C5=CC=C(C(C=C53)=O)OC)C=C(C(OC)=C4OC)OC)=O)=O)[H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang C,et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37(1):411-420. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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100 mg

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