Deac-SS-Biotin

Cat. No.: HY-144793: FAQs
Data Sheet Handling Instructions

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Deac-SS-Biotin is a potent antitumor agent. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity.

For research use only. We do not sell to patients.

Deac-SS-Biotin Chemical Structure

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References
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Description

In Vitro

Deac-SS-Biotin (compound 9) (5 µM; 24 h) has a remarkable reduction-responsive drug release^[1].
Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin^[1].
Deac-SS-Biotin (5 µM, 5 µM and 10 µM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	SGC-7901, A549, Hela, L929 cells
Concentration:	0-20 µM
Incubation Time:	72 h
Result:	Showed potent antiproliferative activity with IC₅₀s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells.

Cell Viability Assay^[1]

Cell Line:	A549 cells
Concentration:	0.17 µM
Incubation Time:
Result:	Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.

Molecular Weight

763.94

Formula

C₃₅H₄₅N₃O₁₀S₃

SMILES

[H][C@]12NC(N[C@]1(CS[C@H]2CCCCC(OCCSSCCOC(N[C@H]3CCC4=C(C5=CC=C(C(C=C53)=O)OC)C=C(C(OC)=C4OC)OC)=O)=O)[H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang C,et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37(1):411-420. [Content Brief]

Deac-SS-Biotin Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deac-SS-BiotinOthersAntitumoranti-tubulinbiotinA549 cellsantiproliferativeselectiveInhibitorinhibitorinhibit

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