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Cat. No.: HY-144394

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Antitumor agent-45

Antitumor agent-45 (Compound 21) could induce and stimulate A549 cells apoptosis in G0/G1 and G2/M phase. Antitumor agent-45 (Compound 21) inhibits c-Met expression to regulate the growth of tumor cells.

For research use only. We do not sell to patients.

CAS No.: 2581082-74-6
Formula: C₂₈H₁₇BrFN₅O₃
Molecular Weight:570.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antitumor agent-45 Chemical Structure

CAS No.: 2581082-74-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.06 μM Compound: 21	Antiproliferative activity against human A549 cells expressing c-Met after 48 hrs by MTT assay Antiproliferative activity against human A549 cells expressing c-Met after 48 hrs by MTT assay	[PMID: 35227978]
HeLa	IC₅₀	10.87 μM Compound: 21	Antiproliferative activity against human HeLa cells expressing c-Met after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells expressing c-Met after 48 hrs by MTT assay	[PMID: 35227978]
MCF7	IC₅₀	0.11 μM Compound: 21	Antiproliferative activity against human MCF7 cells expressing c-Met after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells expressing c-Met after 48 hrs by MTT assay	[PMID: 35227978]

In Vitro

Antitumor agent-45 (Compound 21) enhibits IC₅₀ values of 1.06, 10.87 and 0.11 μM in A549, Hela and MCF-7 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2581082-74-6
Molecular Weight 570.37
Formula C₂₈H₁₇BrFN₅O₃
SMILES

O=C(C1=CN(C2=NC=CC=C2C1=O)C3=CC=C(C=C3)Br)NC4=CC=C(C(F)=C4)OC5=CC=NC6=C5C=CN6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jianqing Zhang, et al. Synthesis, bioevaluation and molecular dynamics of pyrrolo-pyridine benzamide derivatives as potential antitumor agents in vitro and in vivo. Eur J Med Chem. 2022 Apr 5;233:114215. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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