1. MAPK/ERK Pathway
  2. KLF

ML264 

Cat. No.: HY-19994
Handling Instructions

ML 264 is a potent Krüppel-like factor 5 (KLF5) inhibitor

For research use only. We do not sell to patients.
ML264 Chemical Structure

ML264 Chemical Structure

CAS No. : 1550008-55-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $110 In-stock
5 mg $100 In-stock
10 mg $140 In-stock
50 mg $440 In-stock
100 mg $750 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

ML 264 is a potent Krüppel-like factor 5 (KLF5) inhibitor. ML264 inhibits the MAPK pathway by reducing EGR1 and KLF5 levels. ML 264 decreases proliferation of colorectal cancer cell lines, and inhibits the growth of xenografts in a mouse model of primary tumor development. [1] target : KLF5 IC50: ML264 is highly active (IC50 = 29 nM is a cell-based assay for proliferation of DLD-1 cells, IC50 = 81 nM in a cell-based luciferase assay) [2]. in vitro[1]: ML264, potently inhibits proliferation of colorectal cancer cells in vitro through modifications of the cell-cycle profile. In an established xenograft mouse model of colon cancer, we demonstrate that ML264 efficiently inhibits growth of the tumor within 5 days of treatment. For in vitro experiments, ML264 was dissolved in DMSO In vivo[1]: ML264 was dissolved in the vehicle solution: 80% dH2O, 10% DMSO, and 10% Tween 80. Our in vivo DMPK studies demonstrated that ML264 has 2-hour half-life in mice. Interestingly, ML264 also displays 47% oral bioavailability in mice, a very promising feature for compound development with potential therapeutic advantages.

References
Molecular Weight

384.88

Formula

C₁₇H₂₁ClN₂O₄S

CAS No.

1550008-55-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
ML264
Cat. No.:
HY-19994
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