Antitumor agent-80
Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells.
For research use only. We do not sell to patients.
- CAS No.: 2758520-84-0
- Formula: C24H20ClNO2
- Molecular Weight:389.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antitumor agent-80 (compound 11) (5 μM, 48 h) induces apoptosis and increase in PARP cleavage in tumor cells[1].
Antitumor agent-80 (0-10 μM, 96 h) shows cell growth inhibitory activity against breast and hepatocellular carcinoma cell lines[1].
Growth Inhibitory Activity of Antitumor agent-80 against Hepatocellular Carcinoma and Breast Cancer Cell Line Panel[1].
| hepatocellular carcinoma | IC50 (μM) | breast | IC50 (μM) |
| Huh7 | 1.3 | MCF7 | 3.8 |
| HepG2 | 2.1 | MDA-MB231 | 2.0 |
| SNU475 | 1.7 | MDA-MB468 | 2.8 |
| Hep3B | 3.0 | SKBR3 | 3.5 |
| FOCUS | 2.1 | ZR75 | 7.6 |
| Hep40 | 8.6 | MCF10A | 12.1 |
| PLC-PRF-5 | 9.5 | ||
| Mahlavu | 3.2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh7, Mahlavu, MDA-MB-231, and MCF-7 cells
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Concentration:5 μM
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Incubation Time:48 h
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Result:Caused the increase in PARP cleavage in both breast cancer cells (MCF7 and MDA-MB-231) and hepatocellular carcinoma cells (Mahlavu).
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Cell Line:Huh7, Mahlavu, MDA-MB-231, and MCF-7 cells
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Concentration:10 μM, 5 μM, 2.5 μM
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Incubation Time:96 h
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Result:Caused inhibition in the growth of both breast and hepatocellular carcinoma cell lines.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Athymic nude mice (6-8 weeks old, with Mahlavu cells or MDA-MB-231 cells)[1]
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Dosage:40 mg/kg
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Administration:Orally, twice a week, for 4 weeks
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Result:In the Mahlavu xenografts, had a significant reduction (85%) in tumor volume. For MDA-MB-231 xenografts, resulted in about a 50% decrease in tumor volumes as compared to the control group.
Chemical Information
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CAS No. 2758520-84-0
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Molecular Weight 389.87
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Formula C24H20ClNO2
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SMILES
CC1=CC=CC=C1COC2=CC=C(C3=NOC(C)=C3C4=CC=C(Cl)C=C4)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-80 Related Classifications
HY-151620 Related Classifications
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