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Cat. No.: HY-N10539

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Shishijimicin C

Shishijimicin C is a novel antitumor agent found from the Ascidian Didemnum proliferum. Shishijimicin C shows anti-tumor activity with highly potent cytotoxicities. Shishijimicin C is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CAS No.: 503860-52-4
Formula: C₄₅H₅₀N₄O₁₂S₄
Molecular Weight:967.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Shishijimicin C Chemical Structure

CAS No.: 503860-52-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Shishijimicin C is a novel antitumor agent found from the Ascidian Didemnum proliferum. Shishijimicin C shows anti-tumor activity with highly potent cytotoxicities^[1]. Shishijimicin C is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Shishijimicin C (compound 3) (1.7-6.3 pg/mL) shows high cytotoxicity for 3Y1, Hela and P388 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

3Y1, Hela and P388 cells
Concentration:

1.7-6.3 pg/mL
Incubation Time:
Result:

Showed IC₅₀ values of 4.8, 6.3, and 1.7 pg/mL for 3Y1, Hela and P388 cells, respectively.

Chemical Information

CAS No. 503860-52-4
Molecular Weight 967.16
Formula C₄₅H₅₀N₄O₁₂S₄
SMILES

O=C(C1=C(NC2=CC=C3O)C(C2=C3)=CC=N1)[C@@]([C@@H]([C@H]4O[C@H](OC[C@@H]5NCC)C[C@@H]5OC)O)([C@H](O[C@H]4O[C@@H](C#C/C=C\C#C[C@@]6(C7)O)C(/C6=C\CSSSC)=C(C7=O)NC(OC)=O)C)SC
Structure Classification
- Alkaloids
- Pyridine Alkaloids
- Alkaloids
- Indole Alkaloids
- Others
Initial Source
- Animals
Didemnum proliferum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Naoya Oku, et al. Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1). J Am Chem Soc. 2003 Feb 26;125(8):2044-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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