Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1)

  • J Am Chem Soc. 2003 Feb 26;125(8):2044-5. doi: 10.1021/ja0296780.
Naoya Oku  1 ,  Shigeki Matsunaga ,  Nobuhiro Fusetani
Affiliations
  • 1. Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
PMID: 12590521 DOI: 10.1021/ja0296780
Abstract

Three new compounds of the enediyne Antibiotics, shishijimicins A-C (1-3), have been isolated from the ascidian Didemnum proliferum. They encompass a novel sugar component, which is a conjugation product of a hexose and a beta-carboline, attached to the calicheamicinone aglycone. Their structures have been determined by interpretation of spectral data. Shishijimicins showed extremely potent cytotoxicity against HeLa cells with IC(50) values of 1.8-6.9 pM.

Products