1. Apoptosis
  2. Apoptosis
  3. Antitumor agent-151

Antitumor agent-151 (7k) is a significant HsClpP agonist and an antileukemia drug candidate. Antitumor agent-151 (7k) exhibits remarkably enhanced proteolytic activity of HsClpP (EC50 = 0.79 μM) and antitumor activity in vitro (IC50 = 0.038 μM). Antitumor agent-151 (7k) induces apoptosis.

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Antitumor agent-151 Chemical Structure

Antitumor agent-151 Chemical Structure

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Description

Antitumor agent-151 (7k) is a significant HsClpP agonist and an antileukemia drug candidate. Antitumor agent-151 (7k) exhibits remarkably enhanced proteolytic activity of HsClpP (EC50 = 0.79 μM) and antitumor activity in vitro (IC50 = 0.038 μM). Antitumor agent-151 (7k) induces apoptosis[1].

In Vitro

Antitumor agent-151 (7k) displays a strong activity for inhibition of other AML cell lines. The IC50 values of Molm13, U937, OCI-AML2, THP-1, HL60, KASSUMI, and K562 cell lines are 30.1 ± 2.3, 78.2 ± 3.1, 39.2 ± 0.9, 79.7 ± 0.3, 40.5 ± 0.8, 41.1 ± 1.7, and 131.8 ± 1.5 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor agent-151 (7k, 10 mg/kg, ip, Female BALB/c nude mice bearing Mv4-11 AML cells) shows powerful antitumor efficacy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

389.43

Formula

C22H20FN5O

SMILES

O=C(C1=C(CCN(C1)CC2=CC(C#N)=CC=C2)N3)N=C3NCC4=CC=C(C=C4)F

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Antitumor agent-151 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antitumor agent-151
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HY-162462
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