Antitumor agent-70
Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit.
For research use only. We do not sell to patients.
- CAS No.: 2454133-88-9
- Formula: C21H18N4O2
- Molecular Weight:358.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antitumor agent-70 (compound 8b) (0-50 μM, 24 hours) has excellent anti-tumor proliferative activity, especially against multiple myeloma cell RPMI8226[1]. Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) arrests the cell cycle in G0/G1 phase[1]. Antitumor agent-70 (compound 8b) (0-0.2 μM, 24 hours) can induce apoptosis to inhibit cell proliferation by promoting ROS release cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human myeloma cell line U266, Human multiple myeloma cell line RPMI8226, Human umbilical vein endothelial cells HUVEC
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Concentration:0-50 μM
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Incubation Time:24 hours
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Result:Showed anti-proliferative activity against U266, RPMI8226, HUVEC with an IC50 value of 3.81 μM, 0.12 μM, 12.09 μM respectively.
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Cell Line:RPMI8226
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Concentration:0-0.2 μM
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Incubation Time:24 hours
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Result:Showed a significant increase in the proportion of G0/G1 phase cells while S phase and G2/M phase decreased significantly.
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Cell Line:RPMI8226
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Concentration:0-0.2 μM
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Incubation Time:24 hours
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Result:Induced apoptosis rate increased with increasing concentration. Early apoptosis rate is higher than late apoptosis rate.
Chemical Information
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CAS No. 2454133-88-9
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Molecular Weight 358.39
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Formula C21H18N4O2
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SMILES
O=C(C1=CC=CN=C1)N/N=C/C2=CC=C(C(NC3=CC=C(C)C=C3)=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-70 Related Classifications
HY-149019 Related Classifications
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