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Cat. No.: HY-114313

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Microtubule inhibitor 1

Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC₅₀ value of 9-16 nM in cancer cells.

For research use only. We do not sell to patients.

CAS No.: 2305668-80-6
Formula: C₂₁H₁₉NO₃
Molecular Weight:333.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Microtubule inhibitor 1 Chemical Structure

CAS No.: 2305668-80-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Microtubule inhibitor 1 is an antitumor agent with microtubule polymerization inhibitory activity, with an IC₅₀ value of 9-16 nM in cancer cells^[1].

IC₅₀ & Target

Microtubule polymerization^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-8	IC₅₀	0.015 μM Compound: 24d	Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay	[PMID: 30525584]
HepG2	IC₅₀	0.015 μM Compound: 24d	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30525584]
HUVEC	IC₅₀	0.25 μM Compound: 24d	Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay	[PMID: 30525584]
K562	IC₅₀	0.009 μM Compound: 24d	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 30525584]
KB	IC₅₀	0.016 μM Compound: 24d	Antiproliferative activity against human KB cells after 72 hrs by MTT assay Antiproliferative activity against human KB cells after 72 hrs by MTT assay	[PMID: 30525584]
L02	IC₅₀	0.987 μM Compound: 24d	Cytotoxicity against human LO2 cells after 72 hrs by MTT assay Cytotoxicity against human LO2 cells after 72 hrs by MTT assay	[PMID: 30525584]
MDA-MB-231	IC₅₀	0.015 μM Compound: 24d	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 30525584]

Chemical Information

CAS No. 2305668-80-6
Molecular Weight 333.38
Formula C₂₁H₁₉NO₃
SMILES

O=C(C1=CC(C)=NC2=CC=CC=C12)/C(C)=C/C3=CC=C(OC)C(O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li W, et al. Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity. J Med Chem. 2019 Jan 24;62(2):993-1013. [Content Brief]

Calculators

Molarity Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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