2. Immunology/Inflammation Metabolic Enzyme/Protease Apoptosis
  3. TNF Receptor Interleukin Related MMP
  4. Antitumor agent-173

Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940). Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety.

For research use only. We do not sell to patients.

Antitumor agent-173

Antitumor agent-173 Chemical Structure

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Antitumor agent-173 Related Antibodies

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Description

Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940). Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety[1].

Cellular Effect
Cell Line Type Value Description References
NIH3T3 IC50
> 100 μM
Compound: 4b
Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38972080]
Molecular Weight

525.55

Formula

C28H31NO9
SMILES

COC(C=C1)=CC=C1C2=C(OC(N[C@@H](CC(C)C)C(O)=O)=O)C(C3=C(O)C=C4C(CCC(C)(C)O4)=C3O2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-173 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-173Antitumor agent173Antitumor agent 173TNF ReceptorInterleukin RelatedMMPTumor Necrosis Factor ReceptorTNFRILMatrix metalloproteinases4T1 tumor xenograftCICTCycloicaritinInhibitorinhibitorinhibit

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HY-161821
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