Antitumor agent-170
Antitumor agent-170 (Compound C6) exhibits inhibitory activities against PD-1/PD-L1 interaction and PARP7, with IC50 of 0.342 μM and 7.05 nM. Antitumor agent-170 exhibits a high affinity to human PD-L1, with a Ki of 9.31 nM. Antitumor agent-170 restores the T cell function and increases IFN-γ secretion. Antitumor agent-170 exhibits antitumor efficacy against melanoma in mouse models and good pharmacokinetic characteristics.
For research use only. We do not sell to patients.
- Formula: C59H69ClF3N11O9
- Molecular Weight:1168.70
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PARP7 7.05 nM (IC50) |
Chemical Information
-
Molecular Weight 1168.70
-
Formula C59H69ClF3N11O9
-
SMILES
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=C(C=C(C(OCC4=CN=CC=C4)=C3)CN5CCCC[C@H]5C(NCCOCCOCCNC(C6=CN=C(N=C6)N7CCN(CC7)C(CCOC[C@H](C)NC8=C(C(NN=C8)=O)C(F)(F)F)=O)=O)=O)Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-170 Related Classifications
HY-162644 Related Classifications
Powered by Bioz