2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling Cell Cycle/DNA Damage
  3. JAK HDAC
  4. Antitumor agent-123

Antitumor agent-123 (Copmound 4d) effectively inhibits multiple kinase targets with anti-cancer effects, including JAK2, JAK3, HDAC1 and HDAC6, with IC50 values of 34.6 and 2.6 μM for JAK2 and JAK3, respectively. Antitumor agent-123 exhibits moderate activity in solid tumor models.

For research use only. We do not sell to patients.

Antitumor agent-123

Antitumor agent-123 Chemical Structure

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Antitumor agent-123 Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

Antitumor agent-123 (Copmound 4d) effectively inhibits multiple kinase targets with anti-cancer effects, including JAK2, JAK3, HDAC1 and HDAC6, with IC50 values of 34.6 and 2.6 μM for JAK2 and JAK3, respectively. Antitumor agent-123 exhibits moderate activity in solid tumor models[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
9.3 μM
Compound: 4d
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
[PMID: 37989057]
Jurkat IC50
0.02 μM
Compound: 4d
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
[PMID: 37989057]
MCF7 IC50
9.3 μM
Compound: 4d
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
[PMID: 37989057]
NAMALVA IC50
0.04 μM
Compound: 4d
Cytotoxicity against human NAMALVA cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human NAMALVA cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
[PMID: 37989057]
Molecular Weight

412.80

Formula

C19H14ClFN6O2
SMILES

ClC1=CC(NC2=C3C(N(CC4=CC=C(C(NO)=O)C=C4)C=N3)=NC=N2)=CC=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-123 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-123Antitumor agent123Antitumor agent 123JAKHDACJanus kinaseHistone deacetylasesJAK2 InhibitorJAK3 InhibitorHDAC1 InhibitorHDAC6 InhibitorInhibitorinhibitorinhibit

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