Antitumor agent-59
Antitumor agent-59 (Compound 13b) is a potent antitumor agent. Antitumor agent-59 effectively inhibits the proliferation and migration of HCT116 cells. Antitumor agent-59 induces HCT116 cell apoptosis and arrests the cell cycle at the G2/M phase.
For research use only. We do not sell to patients.
- CAS No.: 2409952-04-9
- Formula: C43H36F2N6O6
- Molecular Weight:770.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.73 μM
Compound: 13b
|
In-vitro antitumor activity against human A549 cells incubated for 72 hrs by CCK8 assay
In-vitro antitumor activity against human A549 cells incubated for 72 hrs by CCK8 assay
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[PMID: 35550978] |
| HCT-116 | IC50 |
0.032 μM
Compound: 13b
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In-vitro antitumor activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay
In-vitro antitumor activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay
|
[PMID: 35550978] |
| HUVEC | IC50 |
0.58 μM
Compound: 13b
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In-vitro cytotoxic activity against human HUVEC cells incubated for 72 hrs by CCK8 assay
In-vitro cytotoxic activity against human HUVEC cells incubated for 72 hrs by CCK8 assay
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[PMID: 35550978] |
| MCF7 | IC50 |
0.2 μM
Compound: 13b
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In-vitro antitumor activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
In-vitro antitumor activity against human MCF7 cells incubated for 72 hrs by CCK8 assay
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[PMID: 35550978] |
Antitumor agent-59 (Compound 13b) (72 h) shows antitumor activities with IC50 values of 0.032 ± 0.0071, 0.20 ± 0.020, 0.73 ± 0.12 and 0.58 ± 0.15 μM against HCT116, MCF-7, A549 and HUVEC cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2409952-04-9
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Molecular Weight 770.78
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Formula C43H36F2N6O6
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SMILES
CN1C2=C(C(N3CCC4=C(C13)NC5=CC=C(C=C54)OC(CCCC(OC6=CC=C7NC8=C(C7=C6)CCN9C(C%10=C(N(C89)C)C=CC(F)=C%10)=O)=O)=O)=O)C=C(C=C2)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-59 Related Classifications
HY-146409 Related Classifications
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