country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-149829

Copy Link Print Information

Antitumor agent-97

Antitumor agent-97 (compound 42) is an anticancer agent. Antitumor agent-97 can effectively inhibit the proliferation and autophagy of MGC 803 cells, and induce apoptosis. Antitumor agent-97 also enhances ROS accumulation in MGC 803 cells. Antitumor agent-97 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 2654024-16-3
Formula: C₂₄H₃₄O₃
Molecular Weight:370.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antitumor agent-97 Chemical Structure

CAS No.: 2654024-16-3

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Antitumor agent-97 (Compound 42; 0-200 μM; 24 h) inhibits cell viability of MGC 803 cells in a dose-dependent manner, with an IC₅₀ value of 20.921 μM^[1].
Antitumor agent-97 (20 μM; 24 h) decreases cell proliferation of MGC 803 cells^[1].
Antitumor agent-97 (20 μM; 24 h) induces apoptosis and inhibits autophagy in MGC 803 cells^[1].
Antitumor agent-97 (20 μM; 0-24 h) enhances ROS accumulation in MGC 803 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MGC 803 cells
Concentration:

0-200 μM
Incubation Time:

24 h
Result:

Suppressed cell viability (IC₅₀ = 20.921 μM).

Cell Proliferation Assay^[1]

Cell Line:

MGC 803 cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Inhibited cell proliferation.

Western Blot Analysis^[1]

Cell Line:

MGC 803 cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Significantly upregulated the protein expression of LC3B-II and p62 and decreased the protein expression of LC3B-I.
Enhanced the protein expression of cleaved caspase-9 and cleaved caspase-3, and decreased the protein expression of B-cell lymphoma-2 (Bcl-2).

Chemical Information

CAS No. 2654024-16-3
Molecular Weight 370.52
Formula C₂₄H₃₄O₃
SMILES

C[C@@]12[C@](CCC3=CC(C(C)C)=CC=C32)([H])[C@](C)([C@H](CC1)O)COC(C4CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mao XD, et al. Synthesis and Bioactivity Evaluation of Nepetaefolin F and Its Analogues. ACS Omega. 2023 Apr 12;8(16):14830-14840. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote