2. Apoptosis
  3. Apoptosis
  4. Bursehernin

Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity.

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Bursehernin Chemical Structure

Bursehernin Chemical Structure

CAS No. : 40456-51-7

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Bursehernin Related Antibodies

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Description

Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity[1][2].

In Vitro

Bursehernin (4.3 µM for MCF-7 cells, 3.7 µM for KKU-M213 cells; 4, 48, 72 h) induces apoptosis and cell cycle arrest at G2/M phase in a time-dependent manner [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bursehernin Related Antibodies

Cell Proliferation Assay [1]

Cell Line: MCF-7, MDA-MB-468, MDA-MB-231, HT-29, KKU-M213, KKU-K100, KKU-M055, L-929, MMNK-1 cells
Concentration: 0-100 µM
Incubation Time: 72 h
Result: Showed anti-proliferative activity with IC50s of 11.96, 8.24, 14.26, 47.53, 3.70, 12.38, 17.38, 26.36, 7.45 µM for MCF-7, MDA-MB-468, MDA-MB-231, HT-29, KKU-M213, KKU-K100, KKU-M055, L-929, MMNK-1 cells, respectively.

Cell Cycle Analysis [1]

Cell Line: MCF-7, KKU-M213 cells
Concentration: 4.3 µM for MCF-7 cells, 3.7 µM for KKU-M213 cells
Incubation Time: 24, 48, 72 h
Result: Induced cell cycle arrest at G2/M phase.

Western Blot Analysis [1]

Cell Line: MCF-7, KKU-M213 cells
Concentration: 4.3 µM for MCF-7 cells, 3.7 µM for KKU-M213 cells
Incubation Time: 24, 48, 72 h
Result: Decreased the expression of topoisomerase II, STAT 3, cyclin D1, and p21.

Apoptosis Analysis [1]

Cell Line: MCF-7 cells
Concentration: 0, 2.15, 4.30, 8.60 µM
Incubation Time: 24, 48, 72, 96 h
Result: Induced apoptosis in a time- and dose-dependent manner.
Molecular Weight

370.40

Formula

C21H22O6
CAS No.
SMILES

O=C1OC[C@H](CC2=CC=C(OCO3)C3=C2)[C@H]1CC4=CC(OC)=C(C=C4)OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bursehernin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bursehernin40456-51-7MethylpluviatolideApoptosisanti-proliferativeapoptosisG2/M phaseMCF-7KKU-M213 cellsSTAT 3cyclin D1Inhibitorinhibitorinhibit

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