Neuroinflammatory-IN-3
Neuroinflammatory-IN-3, a tubulin inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization[1].
For research use only. We do not sell to patients.
- CAS No.: 1202404-23-6
- Formula: C19H19ClO3
- Molecular Weight:330.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Neuroinflammatory-IN-3 (compound 1) inhibits LPS-mediated NO release in BV-2 microglial cells down to 70% at a 10 μM concentration, with an IC50 of 5.22 μM. Neuroinflammatory-IN-3 binds to the Colchicine-binding domain of tubulin[1].
Neuroinflammatory-IN-3 (compound 1; 72 hours) is antiproliferative toward HeLa, U266, A549, and MCF7 cell lines with IC50 values of 450 nM, 416 nM, 381 nM, and 744 nM, respectively[2].
Neuroinflammatory-IN-3 (compound 1; 1 μM; 3-12 hours) triggers cell-cycle arrest in a time-dependent manner[2].
Neuroinflammatory-IN-3 (compound 1) inhibits tubulin polymerization in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:1 μM
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Incubation Time:3 h, 6 h, 12 h
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Result:Triggered cell-cycle arrest.
Chemical Information
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CAS No. 1202404-23-6
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Molecular Weight 330.81
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Formula C19H19ClO3
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SMILES
OC1=C(OC)C=CC2=C1OC(C)(C)C=C2C3=CC=C(Cl)C=C3C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Junhyeong Yim, et al. Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuroinflammatory agents by modulating the tubulin-p65 interaction. Exp Mol Med. 2022 Dec 12;1-10 [Content Brief]
[2]. Jongmin Park, et al. Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis. Angew Chem Int Ed Engl. 2012 May 29;51(22):5447-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neuroinflammatory-IN-3 Related Classifications
HY-152088 Related Classifications
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