Search Result

Results for "

β+catenin

" in MedChemExpress (MCE) Product Catalog:

標的別:	β-catenin (268) Adrenergic Receptor (6) Akt (24) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (2) Aminopeptidase (1) AMPK (4) Amyloid-β (4) Androgen Receptor (3) Antibiotic (15) Apoptosis (76) Arf Family GTPase (1) Arginase (2) Atg8/LC3 (2) Aurora Kinase (1) Autophagy (19) Bacterial (23) Bcl-2 Family (11) Bcr-Abl (1) Beclin1 (1) Beta-secretase (1) Biochemical Assay Reagents (5) c-Myc (16) Cadherin (4) Carbonic Anhydrase (1) Carboxylesterase (CES) (1) Carboxypeptidase (1) Casein Kinase (5) Caspase (6) CaSR (1) CDK (21) CDKL (1) Ceramidase (1) Cholinesterase (ChE) (1) Claudin (1) Collagen (2) COX (5) CXCR (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (1) Deubiquitinase (3) DNA Methyltransferase (1) DNA/RNA Synthesis (3) Drug Derivative (1) Drug Metabolite (4) DYRK (2) E1/E2/E3 Enzyme (5) EGFR (2) Endogenous Metabolite (15) Environmental Pollutants (2) Epigenetic Reader Domain (1) ERK (16) Estrogen Receptor/ERR (1) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (3) Fluorescent Dye (2) Fungal (6) Glucocorticoid Receptor (4) Glycoprotein VI (1) GSK-3 (36) HDAC (2) Heme Oxygenase (HO) (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) Histone Demethylase (6) HSP (4) IKK (3) Influenza Virus (1) Interleukin Related (9) Isotope-Labeled Compounds (10) JAK (4) JNK (14) Kallikrein (1) Keap1-Nrf2 (3) Lipoxygenase (2) LXR (1) MAP3K (1) MDM-2/p53 (8) MEK (2) Microtubule/Tubulin (4) Mitochondrial Metabolism (4) Mitophagy (2) MMP (6) Molecular Glues (4) mTOR (7) Na+/H+ Exchanger (NHE) (1) nAChR (4) Natriuretic Peptide Receptor (NPR) (1) Necroptosis (1) Neurokinin Receptor (1) Neuropeptide Y Receptor (1) NF-κB (20) NO Synthase (2) NOD-like Receptor (NLR) (4) Notch (1) Nuclear Factor of activated T Cells (NFAT) (4) Organoid (9) Oxidative Phosphorylation (1) P-glycoprotein (2) p38 MAPK (15) p62 (2) Parasite (9) PARP (13) Phosphodiesterase (PDE) (5) PI3K (8) Porcupine (3) Potassium Channel (4) PPAR (4) Prostaglandin Receptor (1) PROTACs (5) Protease Activated Receptor (PAR) (1) Pyroptosis (3) Pyruvate Carboxylase (PC) (1) Pyruvate Kinase (1) RANKL/RANK (7) RAR/RXR (3) Ras (2) Reactive Oxygen Species (ROS) (21) Reference Standards (47) ROCK (1) RUNX (2) SARS-CoV (2) sFRP-1 (1) Sirtuin (1) Src (1) STAT (7) Survivin (3) Tau Protein (3) TGF-beta/Smad (13) TGF-β Receptor (3) TNF Receptor (4) Toll-like Receptor (TLR) (6) Topoisomerase (2) Transthyretin (TTR) (1) Tyrosinase (1) VEGFR (3) Wee1 (2) Wnt (240) YAP (1) α-synuclein (1)
研究分野別:	Cancer (286) Cardiovascular Disease (19) Endocrinology (15) Infection (24) Inflammation/Immunology (75) Metabolic Disease (56) Neurological Disease (63)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

380

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Targets Recommended: β-catenin

製品番号	製品名	Target	研究分野	構造式

HY-12238

IWR-1 60+ Cited Publications endo-IWR 1; IWR-1-endo	Organoid Wnt	Inflammation/Immunology Cancer
IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting *Wnt/β-catenin* (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

HY-120697

MSAB 45+ Cited Publications	Wnt β-catenin	Cancer
MSAB is a potent and selective inhibitor of *Wnt/β-catenin* signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells .

HY-101085

SKL2001 60+ Cited Publications	Wnt β-catenin	Cancer
SKL2001 is an agonist of the *Wnt/β-catenin* pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction .

HY-P10925

Zolucatetide FOG-001; I-66	β-catenin	Cancer
Zolucatetide (FOG-001;I-66) is a potent *β-catenin* inhibitor with an IC₅₀ of <50 nM. Zolucatetide can inhibits *β-catenin* and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer .

HY-18988

ETC-159 5+ Cited Publications ETC-1922159	Porcupine Wnt	Cancer
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. ETC-159 inhibits β-catenin reporter activity with an IC₅₀ of 2.9 nM.

HY-N0101

Neohesperidin 5+ Cited Publications Hesperetin 7-O-neohesperidoside	β-catenin Wnt	Inflammation/Immunology
Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the *Wnt/β-catenin* signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells .

HY-109103

Tegatrabetan 5 Publications Verification Tegavivint; BC2059	β-catenin	Cancer
Tegatrabetan (BC2059) is a *β-Catenin* antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) .

HY-100760

Toxoflavin 5+ Cited Publications Xanthothricin; Toxoflavine; PKF-118-310	β-catenin Bacterial Antibiotic Histone Demethylase	Infection Cancer
Toxoflavin (Xanthothricin) is an antagonist of *transcription factor 4 (TCF4)/β-catenin* complex, also acts as an inhibitor of KDM4A**, with antitumor and antibiotic activity .

HY-N0060B

(E)-Ferulic acid 1 Publications Verification (E)-Coniferic acid	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite	Cancer
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-13815

KY02111 5 Publications Verification	Wnt	Cardiovascular Disease
KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration .

HY-151520

*Wnt/β-catenin* agonist 4**	Wnt	Cancer
Wnt/β-catenin agonist 4 (Derivative 83) is an agonist of Wnt that activates *Wnt/β-catenin* signal transmission .

HY-P5819

xStAx-VHLL 3 Publications Verification	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin* signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-122649

UU-T01	β-catenin	Cancer
UU-T01 is a *β-catenin* inhibitor with a K_D of 0.531 μM. UU-T01 binds to the K435, R469 and K508 residues of β-catenin, disrupting the β-catenin/TCF4 protein-protein interaction .

HY-111760

NRX-252262	Molecular Glues β-catenin E1/E2/E3 Enzyme	Cancer
NRX-252262 is a potent enhancer of the interaction between *β-Catenin, and its cognate E3 ligase, SCF ^β-TrCP, induces mutant β-catenin* degradation, with an EC₅₀ of 3.8 nM .

HY-B1057

Nefopam hydrochloride 3 Publications Verification Fenazoxine hydrochloride	β-catenin	Neurological Disease Cancer
Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .

HY-172920

*Wnt/β-catenin-IN-6*	Wnt β-catenin EGFR ERK COX Akt GSK-3 c-Myc Apoptosis Interleukin Related JNK	Inflammation/Immunology Cancer
Wnt/β-catenin-IN-6 is an orally active *Wnt/β-catenin* pathway inhibitor. Wnt/β-catenin-IN-6 blocks the *AKT/GSK-3β/β-catenin* signaling pathway, leading to reduced expression of Wnt target genes (c-Myc, c-Jun). Wnt/β-catenin-IN-6 reduces COX2 expression and IL-8 levels, highlighting its dual anti-inflammatory and antitumor effects. Wnt/β-catenin-IN-6 can induce apoptosis. Wnt/β-catenin-IN-6 serves as a tool for non-small cell lung cancer (NSCLC) research .

HY-111836

NRX-252114	Molecular Glues β-catenin	Cancer
NRX-252114 is a potent enhancer of the interaction between *β-catenin, and its cognate E3 ligase, SCF ^β-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin* peptide for β-TrCP with an EC₅₀ of 6.5 nM and a K_d of 0.4 nM. NRX-252114 induces mutant β-catenin degradation .

HY-141448

NRX-2663 1 Publications Verification	β-catenin E1/E2/E3 Enzyme	Cancer
NRX-2663 is an enhancer of the interaction between *β-catenin, and its cognate E3 ligase, SCF ^β-TrCP. NRX-2663 enhances the binding of β-catenin* peptide for β-TrCP with an EC₅₀ of 22.9 μM and a K_d of 54.8 nM .

HY-102028

KY1220 3 Publications Verification	Wnt β-catenin	Cancer
KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the *Wnt/β-catenin* pathway, with an IC₅₀ of 2.1 μM in HEK293 reporter cells .

HY-147007

β-catenin-IN-3 1 Publications Verification	β-catenin Wnt CDK	Cancer
β-catenin-IN-3 (Compound C2) is a selective *β-catenin* inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K_D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells .

HY-18959

CWP232228 5+ Cited Publications	β-catenin Wnt	Cancer
CWP232228, a highly potent selective *Wnt/β-catenin* signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .

HY-138301

Miclxin 1 Publications Verification DS37262926	Wnt β-catenin Apoptosis	Cancer
Miclxin (DS37262926) is a potent inhibitor of mutant *β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60*, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex .

HY-161719

NF764 1 Publications Verification	β-catenin	Cancer
NF764 is a potent *β-catenin* (CTNNB1) degrader. NF764 reduces CTNNB1 protein levels in a proteasome-dependent manner. NF764 can be used in the study of cancer .

HY-144984

NRX-1933	β-catenin Molecular Glues	Cancer
NRX-1933 is a type of molecular glue. NRX-1933 is a *β-catenin*:β-TrCP interaction enhancer for the development of small molecule degraders. NRX-1933 promotes the ubiquitination of mutated β-Catenin, leading to degradation. NRX-1933 can be applied to tumor research on abnormal activation of Wnt/β - catenin signaling pathway .

HY-108442

JW67 1 Publications Verification	Wnt	Cancer
JW67 inhibits the canonical Wnt signaling with an IC₅₀ of 1.17μM . JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth .

HY-136464

β-catenin-IN-2 3 Publications Verification	β-catenin	Cancer
β-catenin-IN-2 (Compound H1B1) is a potent *β-catenin* inhibitor. β-catenin-IN-2 can be used for the study of colorectal cancer .

HY-148055

*Wnt/β-catenin* agonist 3**	Wnt β-catenin	Cardiovascular Disease
Wnt/β-catenin agonist 3 (compound 98) is a *Wnt/β-catenin* signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis .

HY-141873

*Wnt/β-catenin* agonist 2** 1 Publications Verification	Wnt β-catenin	Others
Wnt/β-catenin agonist 2 is a potent Wnt agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction . (From patent WO2007078113A1, compound 39)

HY-114321

*Wnt/β-catenin* agonist 1** 5+ Cited Publications	Wnt	Cancer
Wnt/β-catenin agonist 1 (compound 3f) is a *Wnt/β-catenin* signalling pathway agonist, with an EC₅₀ of 0.27 μM .

HY-115539

Windorphen	Wnt β-catenin Histone Acetyltransferase	Cancer
Windorphen is a *Wnt/β-catenin* signal inhibitor that specifically targets the function of the c-terminal transactivation domain of *β-catenin-1* but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP .

HY-112359

C-82	β-catenin Wnt	Cancer
C-82 is a second-generation specific *CBP/β-catenin* antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300 .

HY-P5819A

xStAx-VHLL TFA 3 Publications Verification	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of *β-catenin. xStAx-VHLL TFA inhibits the Wnt/β-catenin* signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-141450

NRX-103095	β-catenin	Cancer
NRX-103095 is an enhancer of the interaction between *β-catenin, and its cognate E3 ligase, SCF ^β-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin* peptide for β-TrCP with an EC₅₀ of 163 nM .

HY-141449

NRX-103094	Molecular Glues β-catenin	Cancer
NRX-103094 is a potent enhancer of the interaction between *β-catenin, and its cognate E3 ligase, SCF ^β-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin* peptide for β-TrCP with an EC₅₀ of 62 nM and a K_d of 0.6 nM .

HY-112799

DK419	Wnt β-catenin c-Myc CDK Survivin	Cancer
DK419 is a potent and orally active *Wnt/β-catenin* signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK .

HY-160709

*Wnt/β-catenin-IN-2*	Wnt β-catenin	Cancer
Wnt/β-catenin-IN-2 (Compound 3235-0367) is a *Wnt/β-catenin* signaling pathway inhibitor, with IC₅₀ and K_D values of 7.1 and 2.5 μM, respectively. Wnt/β-catenin-IN-2 can be used for the research of cancer .

HY-119383

iCRT-5	Wnt β-catenin	Cancer
iCRT-5 is a β-catenin-regulated transcription (CRT) inhibitor. iCRT-5 can block *Wnt/β-catenin* reporter activity and down regulate β-catenin expression. iCRT-5 can be used for the research of multiple myeloma .

HY-P10392B

aStAx-35R TFA	β-catenin Wnt	Cancer
aStAx-35R TFA, a stapled peptide, antagonizes nuclear form of *β-catenin* and inhibits Wnt signaling. aStAx-35R TFA inhibits competitively the binding of β-catenin to TCF4. aStAx-35R TFA selectively induces growth inhibition of Wnt-dependent cancer cells .

HY-163409

CGK012	Wnt β-catenin	Inflammation/Immunology Cancer
CKG012 is an inhibitor for *Wnt/βcatenin* signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer .

HY-119966

CCT036477	Wnt β-catenin PPAR CDK	Cancer
CCT036477 is a *Wnt/β-catenin* pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2) .

HY-P11112

PTD-DBM	β-catenin Wnt Collagen	Inflammation/Immunology
PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a *Wnt/β-catenin* pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing .

HY-N0060BS

(E)-Ferulic acid-d3 (E)-Coniferic acid-d₃	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite	Cancer
(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299 .

HY-160765

WNTinib APS-8-100-2	Wnt Apoptosis	Cancer
WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes *β-catenin* (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation .

HY-147651

β-catenin-IN-4	β-catenin CDK c-Myc	Cancer
β-catenin-IN-4 (Compound 39) is a *β-catenin* inhibitor with a K_i of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc .

HY-160488

*PTK7/β-catenin-IN-1*	β-catenin	Cancer
PTK7/β-catenin-IN-1 (compound 01065) is a potent *PTK7/β-catenin* inhibitor with an IC₅₀ of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research .

HY-115543

β-catenin-IN-37	Wnt β-catenin	Cancer
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC₅₀ values of 20 μM and 31 μM, respectively .

HY-173482

*TFAP4/Wnt/β-catenin-IN-1*	Wnt β-catenin	Cancer
TFAP4/Wnt/β-catenin-IN-1 (Compound A61) is an orally active *TFAP4/Wnt/β-catenin* inhibitor. TFAP4/Wnt/β-catenin-IN-1 has significant anticancer activity against a variety of cancer cells (such as gastric cancer, lung cancer, breast cancer, etc.), and has the strongest anticancer activity against MGC-803 gastric cancer cells (IC₅₀: 3.92 μM). TFAP4/Wnt/β-catenin-IN-1 induces apoptosis and cell cycle arrest (S phase) in cancer cells by inhibiting the TFAP4/Wnt/β-catenin signaling pathway. TFAP4/Wnt/β-catenin-IN-1 can be used in the study of gastric cancer .

HY-121118

Coronaridine 1 Publications Verification	Wnt	Neurological Disease Cancer
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression .

HY-179408

β-catenin-IN-9	β-catenin Apoptosis	Cancer
β-catenin-IN-9 is a *β-catenin* inhibitor. β-catenin-IN-9 induces apoptosis, cell cycle arrest, and inhibits migration, invasion, and epithelial-mesenchymal transition (EMT) in colorectal cancer cells. β-catenin-IN-9 suppresses the transcription of *β-catenin* and vimentin, and significantly inhibits *β-catenin* at the protein level. β-catenin-IN-9 can be used for the research of colorectal cancer .

HY-163768

Antitumor agent-172	β-catenin	Inflammation/Immunology Cancer
Antitumor agent-172 (Compound 28) is an inhibitor for *β-catenin/BCL9* interaction with IC₅₀ of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with K_d of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models .

製品番号	製品名	Category	Target	構造式

HY-100381

Nigericin sodium salt Maximum Cited Publications 221 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of *Wnt/β-catenin* signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

HY-N0020

Echinacoside 15+ Cited Publications	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants Source Classification	Wnt Reactive Oxygen Species (ROS)
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits *Wnt/β-catenin* signaling**. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .

HY-N0527

Pentagalloylglucose 10+ Cited Publications Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	Infection other families Classification of Application Fields Anti-aging Phenols Polyphenols Plants Disease Research Fields Source Classification	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS) E1/E2/E3 Enzyme
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the *GSK3β/β-catenin* pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

HY-N1499

Nystose	Structural Classification Polysaccharides Classification of Application Fields Rubiaceae Metabolic Disease Plants Morinda officinalis How Disease Research Fields Saccharides Source Classification	Wnt β-catenin TGF-beta/Smad Bacterial
Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose. Nystose exhibits prebiotic, immunomodulatory, and metabolism regulating activities. Nystose promotes the bone mineralization by activating the *Wnt/β-catenin* signaling pathway .

HY-N0101

Neohesperidin 5+ Cited Publications Hesperetin 7-O-neohesperidoside	Flavonoids other families Classification of Application Fields Flavonones Rutaceae Phenols Polyphenols Plants Citrus Inflammation/Immunology Disease Research Fields Source Classification	β-catenin Wnt
Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the *Wnt/β-catenin* signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells .

HY-N1411

Platycodin D 5+ Cited Publications	Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	AMPK Wnt
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. *WNT/β-catenin* pathway mediates the anti-adipogenic effect of platycodin D .

HY-100711

Prodigiosin 3 Publications Verification Prodigiosine; NSC47147	Anti-inflammation/Immunoregulatory Antifungal Classification of Application Fields Antibacterial Disease Research Other Antibiotics Food Research Infection Microorganisms Antibiotics Pigments Anticancer Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Apoptosis Wnt Fungal Parasite
Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the *Wnt/β-catenin* pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-N0753

Eupalinolide B	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Source Classification Cancer	Apoptosis Autophagy Reactive Oxygen Species (ROS) GSK-3 β-catenin MAP3K JNK NF-κB p38 MAPK
Eupalinolide B is a germ sesquiterpene. Eupalinolide B can be isolated from Eupatorium lindleyanum. Eupalinolide B induces Apoptosis, elevates ROS, promotes Autophagy. regulates *GSK-3β/β-catenin, targets UBE2D3* and TAK1, activates ROS-ER-JNK, inhibits NF-κB and MAPKs. Eupalinolide B has anticancer activity against pancreatic cancer and liver cancer. Eupalinolide B relieves rheumatoid arthritis, acute lung injury, periodontitis, depression .

HY-N7030

5,7,3',4'-Tetramethoxyflavone 2 Publications Verification	Infection Flavonoids Classification of Application Fields Flavones Rutaceae Plants Disease Research Fields Murraya exotica L. Mant. Source Classification	Fungal Parasite Bacterial
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .

HY-75342

Methyl vanillate 2 Publications Verification	Monophenols Microorganisms Oryza sativa Linn. Gramineae Phenols Plants Source Classification	Wnt Reactive Oxygen Species (ROS) Endogenous Metabolite
Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a *Wnt/β-catenin* pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

HY-115385

Lumichrome 2 Publications Verification	天然物 Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis MDM-2/p53 Akt β-catenin Nuclear Factor of activated T Cells (NFAT) NF-κB ERK p38 MAPK
Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for *AKT/β-catenin* signaling pathway .

HY-W013812

Ethyl linoleate Linoleic Acid ethyl ester; Mandenol	Cardiovascular Disease Structural Classification Classification of Application Fields Gramineae Setaria italica Plants Disease Research Fields Lipid Source Classification	Tyrosinase Akt GSK-3 β-catenin Biochemical Assay Reagents NF-κB Heme Oxygenase (HO)
Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the *Akt/GSK3β/β-catenin* signaling pathway and the activation of NF-κB. Ethyl linoleate induces heme oxygenase-1 and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics

HY-113283

Homogentisic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ_1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the *Wnt/β-catenin* pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .

HY-N0559

Kirenol 1 Publications Verification	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and *Wnt/β-catenin* pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis .

HY-N0060B

(E)-Ferulic acid 1 Publications Verification (E)-Coniferic acid	Classification of Application Fields Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols Microorganisms other families Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Source Classification Cancer	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-N6790

Nonactin Ammonium ionophore I	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Source Classification	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity .

HY-W002112

(±)-Nornicotine Nornicotine	Structural Classification Alkaloids Pyrrole Alkaloids Neurological Disease Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Metabolite nAChR β-catenin
(±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts *β-catenin* and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .

HY-N0432

Astragaloside I Astrasieversianin IV; Cyclosieversioside B	Triterpenes other families Classification of Application Fields Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Metabolic Disease Plants Disease Research Fields Source Classification	Wnt β-catenin
Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through activating the *Wnt/β-catenin* signaling pathway .

HY-N0279

Cardamonin 15+ Cited Publications Cardamomin; Alpinetin chalcone	Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Boesenbergia rotunda Plants Disease Research Fields Source Classification Zingiberaceae Cancer	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis
Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, *Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-N6031

Dendrophenol 3 Publications Verification Moscatilin	Classification of Application Fields Orchidaceae Phenols Polyphenols Plants Disease Research Fields Dendrobium chrysanthum Wall. ex Lindl. Source Classification Cancer	NF-κB Apoptosis COX HIF/HIF Prolyl-Hydroxylase Wnt β-catenin JNK
Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification by inhibiting the activation of *WNT3/β-catenin* .

HY-129566

Withanolide B	Neurological Disease Classification of Application Fields Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and *Wnt/β-catenin* signaling pathways**. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N0819

Raddeanin A 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK
Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, *Wnt/β-catenin, Wee1, PI3K/AKT* signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma .

HY-N2491

Deoxyelephantopin 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Amorpha fruticosaL. Plants Compositae Disease Research Fields Source Classification Cancer	NF-κB
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and *β-catenin* signaling .

HY-N0665

Specnuezhenide 1 Publications Verification (8E)-Nuezhenide	Structural Classification Monophenols Iridoids Oleaceae Classification of Application Fields Ligustrum lucidum Ait. Terpenoids Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB Wnt
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and *wnt/β-catenin* signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

HY-N1457

Chrysosplenetin 3 Publications Verification	Flavonols Structural Classification Piscidia erythrina L. Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Compositae Disease Research Fields Source Classification	P-glycoprotein Topoisomerase Apoptosis DNA/RNA Synthesis Wnt β-catenin Parasite
Chrysosplenetin is an orally active polymethoxyflavone. Chrysosplenetin exerts anticancer effects by inhibiting topoisomerase, protecting DNA and inducing apoptosis. Chrysosplenetin acts as an antimalarial sensitizer, reverses Artemisinin (HY-B0094) resistance by inhibiting and downregulating P-glycoprotein, and enhances the efficacy of Artemisinin. Chrysosplenetin promotes bone formation by activating the *Wnt/β-catenin* pathway and exerts anti-osteoporotic effects .

HY-N2375

L-Quebrachitol	天然物 other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Wnt β-catenin p38 MAPK
L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and *Wnt/β-catenin* signaling pathway .

HY-N11576

Secalonic acid D	天然物 Microorganisms Classification of Application Fields Sunscreen Cosmetic Research Disease Research Fields Cancer Source Classification	Apoptosis GSK-3 c-Myc β-catenin
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades *β-catenin. Thus, Secalonic acid D down-regulates c-Myc* expression, arrests cell cycle at G1 phase, induces cell apoptosis .

HY-N0899

Wilforine	Cardiovascular Disease Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Celastraceae Tripterygium wilfordii Hook. f. Plants Disease Research Fields Source Classification	JAK STAT Wnt β-catenin
Wilforine is an orally active JAK-STAT pathway inhibitor with immunomodulatory effects and the ability to inhibit osteoclast fusion. Wilforine disrupts lipid raft integrity, reprograms cholesterol and glycosphingolipid metabolic pathways, regulates NF-κB and the complement system, and modulates the expression of various interleukins. Wilforine also inhibits the *Wnt11/β-catenin* signaling pathway and suppresses the proliferation of fibroblast-like synoviocytes. Wilforine can serve as a quality and pharmacokinetic marker for Tripterygium glycoside tablets, and can be applied to research on related diseases such as rheumatoid arthritis, inflammatory osteolysis, and SAPHO syndrome .

HY-N0909

Notoginsenoside R2 1 Publications Verification 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Neurological Disease Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Apoptosis MEK ERK Reactive Oxygen Species (ROS) Caspase COX β-catenin Src MDM-2/p53 JAK STAT
Notoginsenoside R2 (20(S)-Notoginsenoside R2; Ginsenoside Ng-R2) is an orally active notoginsenoside . Notoginsenoside R2 activates P90RSK and Nrf2 via the MEK1/2-ERK1/2 pathway to inhibit 6-OHDA-induced apoptotic damage in nerve cells. Notoginsenoside R2 upregulates *SOX8/β-catenin* by reducing miR-27a, thereby suppressing Aβ_25-35-induced neuronal apoptosis and inflammatory responses . Notoginsenoside R2 alleviates lipid accumulation and mitochondrial dysfunction in diabetic nephropathy by inhibiting c-Src. Notoginsenoside R2 alleviates hepatic fibrosis by inducing hepatic stellate cell senescence and inhibiting the inflammatory microenvironment via JAK/STAT3 suppression . Notoginsenoside R2 can be used in research related to Parkinson's disease, Alzheimer's disease, diabetic nephropathy and hepatic fibrosis .

HY-N0309

Soyasaponin Ba 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc
Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates *Akt/GSK3β/β-catenin* signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .

HY-W100287

Murrayafoline A	Alkaloids Murraya tetramera C. C. Huang Rutaceae Carbazole Alkaloids Plants Source Classification	NF-κB p38 MAPK Interleukin Related IKK JNK β-catenin Wnt
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the *Wnt/β-catenin* pathway by promoting the degradation of intracellular *β-catenin* proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .

HY-N2785

Desmethylicaritin	Flavanonols Flavonoids Epimedium brevicornu Maxim. Plants Berberidaceae Source Classification	Wnt
Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway .

HY-N3149A

2-Hydroxycinnamaldehyde	Monophenols Cinnamomum cassia (L.) D. Don Phenols Plants Lauraceae Source Classification	Wnt β-catenin STAT Apoptosis
2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits *Wnt/β-catenin, STAT3* signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities .

HY-N2156

Paeonolide	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Plants Paeoniaceae Inflammation/Immunology Disease Research Fields Paeonia suffruticosa Andr. Source Classification	ERK TGF-beta/Smad Wnt β-catenin JNK p38 MAPK
Paeonolide, found in Paeonia suffruticosa, is an ERK1/2 activator. Paeonolide promotes early and late osteoblast differentiation, stimulates pre-osteoblast transmigration, and activates the BMP-Smad1/5/8, *Wnt-β-catenin, JNK* and p38 pathways. Paeonolide can be used for the research of osteoporosis, periodontitis .

HY-N3393

Lethedioside A	Aquilaria agallocha Roxb. Structural Classification Flavonoids Flavones Thymelaeaceae Plants Source Classification	β-catenin
Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC₅₀ of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of *TCF4/β-catenin* complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells .

HY-N2523

Gigantol isomer-1 1 Publications Verification	Classification of Application Fields Orchidaceae Phenols Polyphenols Plants Disease Research Fields Dendrobium nobile Lindl. Source Classification Cancer	Wnt
Gigantol isomer-1 is a bibenzyl compound derived from Dendrobium nobile. Gigantol isomer-1 shows promising therapeutic potential against cancer cells. Gigantol isomer-1 is a novel inhibitor of the *Wnt/β-catenin* pathway.

HY-121118

Coronaridine 1 Publications Verification	Apocynaceae Alkaloids Tabernaemontana divaricata (Linnaeus) R. Brown ex Roemer & Schultes Plants Indole Alkaloids Source Classification	Wnt
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression .

HY-N10359

Isoandrographolide	Acanthaceae Classification of Application Fields Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	NOD-like Receptor (NLR) Caspase Akt GSK-3 β-catenin
Isoandrographolide is an orally active NLRP3 inflammasome inhibitor and *AKT/GSK-3β/β-catenin* pathway inhibitor. Isoandrographolide inhibits the expression of NLRP3, ASC, and caspase-1, and reduces the levels of phosphorylated AKT, phosphorylated GSK-3β, and β-catenin. Isoandrographolide alleviates inflammatory responses, reduces collagen deposition, suppresses epithelial-mesenchymal transition (EMT), induces differentiation of leukemia cells, inhibits the growth of leukemia cells, protects lung and kidney tissues, regulates cytokine levels, and also exhibits hepatoprotective effects. Isoandrographolide can be used in studies related to silicosis, murine myeloid leukemia, renal tubulointerstitial fibrosis, and non-alcoholic fatty liver disease .

HY-N7183

9-Hydroxycanthin-6-one	Structural Classification Alkaloids Simaroubaceae Other Alkaloids Plants Source Classification	NF-κB GSK-3 β-catenin Wnt
9-Hydroxycanthin-6-one is a β-carboline alkaloid. 9-Hydroxycanthin-6-one can be isolated from the roots of E. longifolia. 9-Hydroxycanthin-6-one inhibits TNF-α-induced activation of the NF-κB pathway. 9-Hydroxycanthin-6-one activates GSK3β independently of CK1α, drives phosphorylation and degradation of *β-catenin, and inhibits the Wnt* signaling pathway. 9-Hydroxycanthin-6-one exerts selective cytotoxicity against Wnt-dependent colon cancer cells. 9-Hydroxycanthin-6-one can be used in studies related to colon cancer .

HY-N7215

Jatrophone	Microorganisms Terpenoids Diterpenoids Source Classification	β-catenin Wnt
Jatrophone is a diterpenoid with anticancer activity isolated from Jatropha isabelli. Jatrophone interferes with the Wnt/β-catenin pathway to inhibit the proliferation and epithelial-mesenchymal transition (EMT) of triple-negative breast cancer cells.

HY-100711A

Prodigiosin hydrochloride 3 Publications Verification Prodigiosine hydrochloride	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Pigments Inflammation/Immunology Disease Research Fields Source Classification Food Research	Bacterial Apoptosis Fungal Wnt Parasite
Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits *Wnt/β-catenin* pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .

HY-13675

ME-143 NV-143	Structural Classification Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields Source Classification Cancer	Wnt Endogenous Metabolite
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo .

HY-N0020R

Echinacoside (Standard)	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants Source Classification	Reference Standards Wnt Reactive Oxygen Species (ROS)
Echinacoside (Standard) is the analytical standard of Echinacoside. This product is intended for research and analytical applications. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity .

HY-N0060BR

(E)-Ferulic acid (Standard) (E)-Coniferic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms other families Simple Phenylpropanols Phenols Phenylpropanoids Plants Endogenous metabolite Source Classification	Reference Standards β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite
(E)-Ferulic acid (Standard) is the analytical standard of (E)-Ferulic acid. This product is intended for research and analytical applications. (E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-N2199

Sotetsuflavone	Structural Classification Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	Apoptosis Autophagy PI3K JNK mTOR p38 MAPK CDK MMP TGF-beta/Smad STAT β-catenin Reactive Oxygen Species (ROS) Bcl-2 Family Caspase
Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits phosphorylation of PI3K, Akt, mTOR, JNK, and p38 MAPK; modulates expression of Cyclin D1, CDK4, Bcl-2, Bax, cleaved caspases 3/9, MMP-9, TGF-β, STAT3, and *β-catenin. Sotetsuflavone induces G₀/G₁ cell cycle arrest, apoptosis, autophagy, and intracellular ROS* elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease .

HY-N1411R

Platycodin D (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Endogenous metabolite Source Classification	Reference Standards AMPK Wnt
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-111431R

p-Cresyl sulfate (Standard) p-Tolyl sulfate (Standard)	Structural Classification 天然物 Endogenous metabolite Source Classification	Reference Standards JNK p38 MAPK Reactive Oxygen Species (ROS)
Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D .

HY-N1499R

Nystose (Standard)	Structural Classification Polysaccharides Rubiaceae Plants Morinda officinalis How Saccharides Source Classification	Reference Standards Wnt β-catenin TGF-beta/Smad Bacterial
Nystose (Standard) is the analytical standard of Nystose. This product is intended for research and analytical applications. Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose. Nystose exhibits prebiotic, immunomodulatory, and metabolism regulating activities. Nystose promotes the bone mineralization by activating the *Wnt/β-catenin* signaling pathway .

HY-N0527R

Pentagalloylglucose (Standard) Penta-O-galloyl-β-D-glucose (Standard); 1,2,3,4,6-Pentagalloyl glucose (Standard)	Structural Classification other families Phenols Polyphenols Plants Source Classification	Reference Standards JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS)
Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the *GSK3β/β-catenin* pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

HY-N9647

Dalbinol	Flavonoids Leguminosae Amorpha fruticosaL. Plants Other Flavonoids Source Classification	Wnt β-catenin Apoptosis
Dalbinol is a rotenoid compound. Dalbinol can inhibit *Wnt/β-catenin* signaling pathway and promote *β-catenin* degradation. Dalbinol inhibits tumor cells proliferation and induces apoptosis. Dalbinol has antitumor activity .

製品番号	製品名	構造式

HY-N0060BS

(E)-Ferulic acid-d3

(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299 .

HY-W002112S

(±)-Nornicotine-d4

(±)-Nornicotine-d₄ is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .

HY-B0194S

Tizanidine-d4

Tizanidine-d₄ is the deuterium labeled Tizanidine (HY-B0194). Tizanidine, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

HY-B1057S1

Nefopam-d4 hydrochloride
Nefopam-d₄ (hydrochloride) is deuterium labeled Nefopam (hydrochloride). Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .

HY-B1057S2

Nefopam-d3
Nefopam-d₃ is a deuterium labeled Nefopam (Fenazoxine). Nefopam is a centrally-acting but non-opioid analgesic drug, and Nefopam targets β-catenin protein level in mesenchymal cells .

HY-100760S

Toxoflavin-13C4
Toxoflavin- ¹³C₄ is the ¹³C-labeled Toxoflavin. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity . Antibiotic properties.

HY-B1057S

Nefopam-d3 hydrochloride
Nefopam-d₃ (hydrochloride) is the deuterium labeled Nefopam hydrochloride. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .

HY-133115S

N-Desmethylnefopam-d5
N-Desmethylnefopam-d₅ is the deuterium labeled N-Desmethylnefopam (HY-133115). N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .

HY-W002112S1

(±)-Nornicotine-d7

(±)-Nornicotine-d₇ is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia .

HY-75342S

Methyl vanillate-d3
Methyl vanillate-d₃ is deuterated labeled Methyl vanillate (HY-75342). Methyl vanillate, one of the ingredients in Oryza sativa Linn., is a Wnt/β-catenin pathway activator . A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite.

HY-W708917

Lumichrome-d8
Lumichrome-d₈ is the deuterium labeled Lumichrome (HY-115385). Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway .

HY-B0194AS

Tizanidine-d4 hydrochloride

Tizanidine-d₄ hydrochloride is deuterium labeled Tizanidine hydrochloride (HY-B0194A). Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α₂-adrenoceptor agonist (IC₅₀ = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

HY-W142432S

Perfluoroundecanoic acid-13C7

Perfluoroundecanoic acid- ¹³C₇ is the ¹³C-labeled Perfluoroundecanoic acid (HY-W142432). Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .

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Species:	Human (5) Mouse (1)
Tag:	His (6) Strep (1) Avi (1) GST (2)
Source:	Sf9 insect cells (2) E. coli (4)


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Host:	Mouse (7) Rabbit (9)
Reactivity:	Human (16) Rat (14) Mouse (15) Hamster (1)
Application:	IHC-P (8) ICC/IF (7) mIHC (1) IP (6) WB (16) ChIP (1) FC (3) ELISA (6)
Isotype:	IgG, Kappa (1) IgG,Kappa (1) IgG (9) IgG1 (3) IgG2b (2)
Conjugation:	Non-conjugated (16) Biotin (1)
Clonality:	Monoclonal (13) Recombinant (7)
Modification:	Phosphorylated (5) Unmodified (8)


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Size	* This product has been "discontinued". Optimized version of product available: / 在庫あり - + カートに追加お問い合わせ