N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
Based on 1 publication(s) in Google Scholar
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide is a macamide isolated from Maca (Lepidium meyenii Walp.) N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide induces mesenchymal stem cells osteogenic differentiation and consequent bone formation through activating the canonical Wnt/β‐catenin signaling pathway. N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide can be used for the research of osteoporosis.
For research use only. We do not sell to patients.
- Purity : 99.48%
- CAS No.: 883715-23-9
- Formula: C26H39NO2
- Molecular Weight:397.59
-
Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
More
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
100 μM
Compound: 5
|
Inhibition of [ethanol-amine-1-3H]AEA uptake in human U937 cells preincubated for 15 mins measured 15 mins post AEA addition by liquid scintillation counting
Inhibition of [ethanol-amine-1-3H]AEA uptake in human U937 cells preincubated for 15 mins measured 15 mins post AEA addition by liquid scintillation counting
|
[PMID: 24972328] |
| U-937 | IC50 |
19.05 μM
Compound: 5
|
Inhibition of FAAH-mediated [ethanol-amine-1-3H]AEA hydrolysis in human U937 cells preincubated for 15 mins measured 15 mins post AEA addition by liquid scintillation counting
Inhibition of FAAH-mediated [ethanol-amine-1-3H]AEA hydrolysis in human U937 cells preincubated for 15 mins measured 15 mins post AEA addition by liquid scintillation counting
|
[PMID: 24972328] |
Chemical Information
-
CAS No. 883715-23-9
-
Appearance Liquid (Density: 0.961±0.06 g/cm3)
-
Molecular Weight 397.59
-
Formula C26H39NO2
-
Color Colorless to light yellow
-
SMILES
CC/C=C\C/C=C\C/C=C\CCCCCCCC(NCC1=CC=CC(OC)=C1)=O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Toxicol Appl Pharmacol
USP7 inhibitor HBX41108 suppresses osteoblastic differentiation in vitro and disrupts osseointegration of dental implants in vivo. [Abstract]2025 Oct 9:505:117593. PMID: 41067506
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (251.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5152 mL | 12.5758 mL | 25.1515 mL | 62.8788 mL |
| 5 mM | 0.5030 mL | 2.5152 mL | 5.0303 mL | 12.5758 mL | |
| 10 mM | 0.2515 mL | 1.2576 mL | 2.5152 mL | 6.2879 mL | |
| 15 mM | 0.1677 mL | 0.8384 mL | 1.6768 mL | 4.1919 mL | |
| 20 mM | 0.1258 mL | 0.6288 mL | 1.2576 mL | 3.1439 mL | |
| 25 mM | 0.1006 mL | 0.5030 mL | 1.0061 mL | 2.5152 mL | |
| 30 mM | 0.0838 mL | 0.4192 mL | 0.8384 mL | 2.0960 mL | |
| 40 mM | 0.0629 mL | 0.3144 mL | 0.6288 mL | 1.5720 mL | |
| 50 mM | 0.0503 mL | 0.2515 mL | 0.5030 mL | 1.2576 mL | |
| 60 mM | 0.0419 mL | 0.2096 mL | 0.4192 mL | 1.0480 mL | |
| 80 mM | 0.0314 mL | 0.1572 mL | 0.3144 mL | 0.7860 mL | |
| 100 mM | 0.0252 mL | 0.1258 mL | 0.2515 mL | 0.6288 mL |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide Related Classifications
HY-N7702 Related Classifications
Powered by Bioz