UM206_L 

UM206_L is a linear Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical Wnt/β-catenin signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces^[1].

UM206_L (free form) (10 nM-1 mM; 3 h, 24 h) fails to stably regulate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells^[1].
UM206_L-conjugated MNPs (1-10 µg per mg MNP; 1-24 h), when combined with 1 Hz nanomagnetic actuation, potently activate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells in a peptide density-dependent manner in vitro^[1].
UM206_L (immobilized; 1 µg per slide; 3-24 h) retains weak canonical Wnt/β-catenin TCF/LEF signaling activity in HEK293 Luc-TCF/LEF cells on glass substrates, induces a significant increase in signaling at 3 h, and this signaling level is maintained until 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1427.58

C₅₄H₉₀N₁₆O₂₃S₃

1242439-00-4

Ac-Cys-Asn-Lys-Thr-Ser-Glu-Gly-Met-Asp-Gly-Cys-Glu-Leu-NH2

Ac-CNKTSEGMDGCEL-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hu B, et al. Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics. Int J Mol Sci. 2022;23(17):10164. Published 2022 Sep 5.  [Content Brief]