(Rac)-XL177A
Based on 1 Customer Validation
(Rac)-XL177A is the racemic isomer of XL177A (HY-138794). XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections.
For research use only. We do not sell to patients.
- CAS No.: 2417089-73-5
- Formula: C48H57ClN8O5
- Molecular Weight:861.47
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Antiviral Compound Library
HY-L027
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Anti-Aging Compound Library
HY-L034
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Ubiquitination Compound Library
HY-L050
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Anti-Colorectal Cancer Compound Library
HY-L103
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Nuclear Receptor Compound Library
HY-L126
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Metabolic Enzyme Compound Library
HY-L146
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Protease Inhibitor Library
HY-L147
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
Chemical Information
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CAS No. 2417089-73-5
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Appearance Solid
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Molecular Weight 861.47
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Formula C48H57ClN8O5
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SMILES
O=C(C(C=CC1=C2Cl)=CC1=NC3=C2CCCC3)NCCCC(CC4=CC=CC=C4)C(N5CCC(CN6C=NC7=C(C=CC(NC(CCN8CCN(C)CC8)=O)=C7)C6=O)(O)CC5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 70 mg/mL (81.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Abdrabou AM, et al. nuPRISM: Microfluidic Genome-Wide Phenotypic Screening Platform for Cellular Nuclei. ACS Cent Sci. 2022;8(12):1618-1626. [Content Brief]
[3]. Cmarik EA, et al. Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation. Mol Cancer Res. Published online March 19, 2026. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1608 mL | 5.8040 mL | 11.6081 mL | 29.0202 mL |
| 5 mM | 0.2322 mL | 1.1608 mL | 2.3216 mL | 5.8040 mL | |
| 10 mM | 0.1161 mL | 0.5804 mL | 1.1608 mL | 2.9020 mL | |
| 15 mM | 0.0774 mL | 0.3869 mL | 0.7739 mL | 1.9347 mL | |
| 20 mM | 0.0580 mL | 0.2902 mL | 0.5804 mL | 1.4510 mL | |
| 25 mM | 0.0464 mL | 0.2322 mL | 0.4643 mL | 1.1608 mL | |
| 30 mM | 0.0387 mL | 0.1935 mL | 0.3869 mL | 0.9673 mL | |
| 40 mM | 0.0290 mL | 0.1451 mL | 0.2902 mL | 0.7255 mL | |
| 50 mM | 0.0232 mL | 0.1161 mL | 0.2322 mL | 0.5804 mL | |
| 60 mM | 0.0193 mL | 0.0967 mL | 0.1935 mL | 0.4837 mL | |
| 80 mM | 0.0145 mL | 0.0726 mL | 0.1451 mL | 0.3628 mL |
(Rac)-XL177A Related Classifications
HY-138794A Related Classifications
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