1. Stem Cell/Wnt
  2. Wnt
    β-catenin
  3. Astragaloside I

Astragaloside I (Synonyms: Astrasieversianin IV; Cyclosieversioside B)

Cat. No.: HY-N0432 Purity: ≥98.0%
Handling Instructions

Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway.

For research use only. We do not sell to patients.

Astragaloside I Chemical Structure

Astragaloside I Chemical Structure

CAS No. : 84680-75-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 172 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 920 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway[1].

In Vitro

Astragaloside I (10-40 μM) upregulates the express of β-catenin, Runx2, BGP and OPG, RANKL (osteogenesis marker genes) in MC3T3-E1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1].

Cell Line: MC3T3-E1 cells.
Concentration: 0, 10, 20, 40 μM.
Incubation Time: 5 days.
Result: Stimulated the expression of β-catenin and Runx2.

Cell Cytotoxicity Assay[1].

Cell Line: MC3T3-E1 cells.
Concentration: 0, 10, 20, 40 μM.
Incubation Time: 1, 3 or 6 days (The media was changed every 2 days).
Result: No obvious cytotoxic effect was observed in the MC3T3-E1 cells.
Molecular Weight

869.04

Formula

C₄₅H₇₂O₁₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (57.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1507 mL 5.7535 mL 11.5070 mL
5 mM 0.2301 mL 1.1507 mL 2.3014 mL
10 mM 0.1151 mL 0.5753 mL 1.1507 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (3.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.25 mg/mL (3.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Astragaloside I
Cat. No.:
HY-N0432
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