Sodium acetate trihydrate, 99.5%
Based on 1 Customer Validation
Sodium acetate trihydrate, 99.5% is a carboxylic acid and short-chain fatty acid (SCFAs). Sodium acetate trihydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Sodium acetate trihydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Sodium acetate trihydrate regulates energy metabolism. Sodium acetate trihydrate has anticancer activity against gastric cancer. Sodium acetate trihydrate induces writhing reaction and ulcerative colitis. Sodium acetate trihydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 6131-90-4
- Formula: C2H4O2.3H2O.Na
- Molecular Weight:137.09
-
Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Apoptosis Compound Library
HY-L003
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Epigenetics Compound Library
HY-L005
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
NF-κB Signaling Compound Library
HY-L014
-
PI3K/Akt/mTOR Compound Library
HY-L015
-
Anti-Cancer Compound Library
HY-L025
-
Human Endogenous Metabolite Compound Library
HY-L030
-
Anti-Aging Compound Library
HY-L034
-
Antioxidant Compound Library
HY-L037
-
Oxygen Sensing Compound Library
HY-L045
-
Antifungal Compound Library
HY-L048
-
Glycolysis Compound Library
HY-L058
-
Cytoskeleton Compound Library
HY-L060
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Microbial Metabolite Library
HY-L084
-
Anti-Obesity Compound Library
HY-L087
-
Transcription Factor-Targeted Library
HY-L090
-
Lipid Metabolism Compound Library
HY-L091
-
Glucose Metabolism Compound Library
HY-L092
-
Antidepressant Compound Library
HY-L108
-
Nuclear Receptor Compound Library
HY-L126
-
Pain-Related Compound Library
HY-L139
-
Mitochondrial Protection Compound Library
HY-L144
-
Metabolic Enzyme Compound Library
HY-L146
-
Animal-Sourced Natural Product Library
HY-L157
-
Multi-Target Compound Library
HY-L176
-
Radioprotector Library
HY-L178
-
MCE Bioactive Compound Library
HY-L001V
-
Anti-Gastric Cancer Compound Library
HY-L184
-
Anti-Fibrosis Compound Library
HY-L185
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
Lactic Acid Metabolic Compound Library
HY-L204
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
Biological Activity
|
Microbial Metabolite |
Human Endogenous Metabolite |
PPARα |
Caspase 9 |
Sodium acetate trihydrate (Acetic acid; 2-5 µM; 24 h) induces cancer cell-selective death in gastric cancer cells (RGK1) via oxidative stress, while having minor effects on normal gastric mucosal cells (RGM1)[3].
Sodium acetate trihydrate (Acetic acid; 20-200 mM; 200 min) induces programmed cell death in Saccharomyces cerevisiae W303-1A[4].
Sodium acetate trihydrate (Acetic acid; 5 mM; 15 d) suppresses the increase in disaccharidase activity (sucrase, maltase, trehalase, lactase) in Caco-2 cells without affecting cell growth or glucose transport[5].
Sodium acetate trihydrate (Acetic acid; 1.8-7.2 mM; 3 h) activates the AMPKα signaling pathway by consuming ATP to increase the AMP/ATP ratio in bovine hepatocytes, upregulating lipid oxidation genes, downregulating lipogenic genes, and reducing intracellular triglyceride content[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Rat gastric mucosal cells (RGM1), cancerous gastric mucosal cells (RGK1)
-
Concentration:0, 1, 2, 5, 10, 20 µM
-
Incubation Time:24 h
-
Result:Increased monocarboxylic transporter 1 (MCT1) and cleaved caspase 9 in RGK1 cells.
Showed minor effects in RGM1 cells.
-
Cell Line:Bovine hepatocytes
-
Concentration:1.8 mM, 3.6 mM, 7.2 mM
-
Incubation Time:3 h
-
Result:Increased AMPKα phosphorylation and activity, upregulated PPARα expression, downregulated SREBP-1c and ChREBP expression.
Sodium acetate trihydrate (Acetic acid; 5% v/v; rectal instillation) induces ulcerative colitis in mice, causing weight loss, diarrhea, colonic inflammation, and tissue damage[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 6131-90-4
-
Appearance Solid
-
Molecular Weight 137.09
-
Formula C2H4O2.3H2O.Na
-
Color White to off-white
-
SMILES
O=C(C)O.[Na].O.O.O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : ≥ 200 mg/mL (1458.90 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Syka JE, et al. Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9528-33. [Content Brief]
[3]. Terasaki M, et al. Acetic acid is an oxidative stressor in gastric cancer cells. J Clin Biochem Nutr. 2018 Jul;63(1):36-41. [Content Brief]
[4]. Ludovico P, et al. Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology (Reading). 2001 Sep;147(Pt 9):2409-2415. [Content Brief]
[5]. Ogawa N, et al. Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of caco-2 cells. J Nutr. 2000 Mar;130(3):507-13. [Content Brief]
[6]. Li X, et al. Acetic acid activates the AMP-activated protein kinase signaling pathway to regulate lipid metabolism in bovine hepatocytes. PLoS One. 2013 Jul 4;8(7):e67880. [Content Brief]
[7]. Stevenson GW, et al. Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice. J Pain. 2006 Jun;7(6):408-16. [Content Brief]
[8]. Niu X, et al. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):256-65. [Content Brief]
[9]. Granado-Serrano AB, et al. Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia. Sci Rep. 2019 Feb 11;9(1):1772. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.2945 mL | 36.4724 mL | 72.9448 mL | 182.3620 mL |
| 5 mM | 1.4589 mL | 7.2945 mL | 14.5890 mL | 36.4724 mL | |
| 10 mM | 0.7294 mL | 3.6472 mL | 7.2945 mL | 18.2362 mL | |
| 15 mM | 0.4863 mL | 2.4315 mL | 4.8630 mL | 12.1575 mL | |
| 20 mM | 0.3647 mL | 1.8236 mL | 3.6472 mL | 9.1181 mL | |
| 25 mM | 0.2918 mL | 1.4589 mL | 2.9178 mL | 7.2945 mL | |
| 30 mM | 0.2431 mL | 1.2157 mL | 2.4315 mL | 6.0787 mL | |
| 40 mM | 0.1824 mL | 0.9118 mL | 1.8236 mL | 4.5590 mL | |
| 50 mM | 0.1459 mL | 0.7294 mL | 1.4589 mL | 3.6472 mL | |
| 60 mM | 0.1216 mL | 0.6079 mL | 1.2157 mL | 3.0394 mL | |
| 80 mM | 0.0912 mL | 0.4559 mL | 0.9118 mL | 2.2795 mL | |
| 100 mM | 0.0729 mL | 0.3647 mL | 0.7294 mL | 1.8236 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium acetate trihydrate, 99.5% Related Classifications
HY-Y1325I Related Classifications
Powered by Bioz