NRX-103094
Based on 1 Customer Validation
NRX-103094 is a Molecular glue and β-catenin/β-TrCP interaction enhancer, with an EC50 of 62 nM for the binding of pSer33/S37A β-catenin peptide to recombinant β-TrCP/Skp1 complex. NRX-103094 shows selectivity for Ser37 phosphorylation-deficient β-catenin, and has no effect on wild-type doubly phosphorylated β-catenin or other β-TrCP substrates. NRX-103094 can be used in research related to colorectal cancer and ovarian endometrioid adenocarcinoma.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 2763260-36-0
- Formula: C20H11Cl2F3N2O4S
- Molecular Weight:503.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
EC50: 62 nM (β-catenin:β-TrCP Interaction)[1]
Kd: 0.6 nM (β-catenin:β-TrCP Interaction)[1]
In Vitro
NRX-103094 acts as a canonical molecular glue, enhancing the binding affinity between β-catenin degron peptide and β-TrCP E3 ligase without detectable individual affinity for either protein partner[1].
NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide to recombinant β-TrCP/Skp1 complex in a TR-FRET assay with an EC50 of 457 nM[2].
NRX-103094 enhances the binding of pSer33/S37A β-catenin peptide to recombinant β-TrCP/Skp1 complex in a TR-FRET assay with an EC50 of 62 nM and 1000-fold binding cooperativity at 40 μM[2].
NRX-103094 (0.006-25 μM) dose-dependently potentiates ubiquitylation of pSer33/S37A β-catenin peptide by recombinant SCFβ-TrCP, achieving levels exceeding WT β-catenin peptide at 250 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2763260-36-0
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Appearance Solid
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Molecular Weight 503.28
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Formula C20H11Cl2F3N2O4S
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Color White to off-white
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SMILES
OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)=O)=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (99.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (287 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9870 mL | 9.9348 mL | 19.8697 mL | 49.6741 mL |
| 5 mM | 0.3974 mL | 1.9870 mL | 3.9739 mL | 9.9348 mL | |
| 10 mM | 0.1987 mL | 0.9935 mL | 1.9870 mL | 4.9674 mL | |
| 15 mM | 0.1325 mL | 0.6623 mL | 1.3246 mL | 3.3116 mL | |
| 20 mM | 0.0993 mL | 0.4967 mL | 0.9935 mL | 2.4837 mL | |
| 25 mM | 0.0795 mL | 0.3974 mL | 0.7948 mL | 1.9870 mL | |
| 30 mM | 0.0662 mL | 0.3312 mL | 0.6623 mL | 1.6558 mL | |
| 40 mM | 0.0497 mL | 0.2484 mL | 0.4967 mL | 1.2419 mL | |
| 50 mM | 0.0397 mL | 0.1987 mL | 0.3974 mL | 0.9935 mL | |
| 60 mM | 0.0331 mL | 0.1656 mL | 0.3312 mL | 0.8279 mL | |
| 80 mM | 0.0248 mL | 0.1242 mL | 0.2484 mL | 0.6209 mL |
NRX-103094 Related Classifications
HY-141449 Related Classifications
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