1. Stem Cell/Wnt
  2. Wnt
  3. PRI-724

PRI-724 

Cat. No.: HY-112045 Purity: 98.31%
Handling Instructions

PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.

For research use only. We do not sell to patients.

PRI-724 Chemical Structure

PRI-724 Chemical Structure

CAS No. : 1422253-38-0

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PRI-724:

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Description

PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.

IC50 & Target

CBP/β-catenin[1]

In Vivo

PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].

Molecular Weight

658.64

Formula

C₃₃H₃₅N₆O₇P

CAS No.

1422253-38-0

SMILES

O=C(N([[email protected]]([[email protected]](C)N1CC2=C3N=CC=CC3=CC=C2)([H])N4[[email protected]@H](CC5=CC=C(OP(O)(O)=O)C=C5)C1=O)N(C)CC4=O)NCC6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
Animal Administration
[1]

Mice[1]

Male wild-type (C57BL/6 and Balb/c) mice aged 8 to 11 weeks or 6 to 9 months are used. CCl4 administration or BDL induced liver fibrosis model is used for this study. The animals are intraperitoneally injected with or without 0.4 mg/mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

PRI-724PRI724PRI 724WntInhibitorinhibitorinhibit

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PRI-724
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HY-112045
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