1. Stem Cell/Wnt
  2. β-catenin
    Wnt
  3. C-82

C-82 

Cat. No.: HY-112359
Handling Instructions

C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.

For research use only. We do not sell to patients.

C-82 Chemical Structure

C-82 Chemical Structure

CAS No. : 1422253-37-9

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Description

C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.

IC50 & Target

CBP/β-catenin[1]

In Vitro

C-82 is an active form of PRI-724. C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].

In Vivo

PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile[1].

Molecular Weight

578.66

Formula

C₃₃H₃₄N₆O₄

CAS No.

1422253-37-9

SMILES

O=C(N1N(C)CC(N([[email protected]]2CC3=CC=C(O)C=C3)[[email protected]]1([H])[[email protected]](C)N(CC4=CC=CC5=C4N=CC=C5)C2=O)=O)NCC6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

The culture-activated hepatic stellate cells (HSCs) are treated with or without C-82 (3, 10 μM) for 5 days. Medium change is not performed after C-82 treatment. Cell viability is examined using XTT based Cell Proliferation Kit[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

C-82C82C 82β-cateninWntBeta cateninInhibitorinhibitorinhibit

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