1. Stem Cell/Wnt
  2. Wnt
    β-catenin
  3. FzM1.8

FzM1.8 

Cat. No.: HY-117163
Handling Instructions

FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K.

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FzM1.8 Chemical Structure

FzM1.8 Chemical Structure

CAS No. : 2204290-85-5

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Description

FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1].

IC50 & Target

pEC50: 6.4 (FzM1.8)[1]

Molecular Weight

322.31

Formula

C₁₈H₁₄N₂O₄

CAS No.

2204290-85-5

SMILES

O=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1

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FzM1.8
Cat. No.:
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