2204290-85-5
Chemical Structure
FzM1.8
- CAS No.: 2204290-85-5
- Formula:C18H14N2O4
- Molecular Weight:322.31
IUPAC Name: 3-hydroxy-5-(3-(naphthalen-2-yl)ureido)benzoic acid
InChIKey: XGNNCRZDDAJBFU-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1
Biological Activity: FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FzM1.8 | 98.93% | FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K. | ||||||||||||||||||||
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Keywords
