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Cat. No.: HY-B0730R

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Pamidronate disodium pentahydrate (Standard)

Name: Pamidronate disodium pentahydrate (Standard)
Brand: MedChemExpress
SKU: HY-B0730R
Price: 92.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Pamidronate (disodium pentahydrate) (Standard) is the analytical standard of Pamidronate (disodium pentahydrate). This product is intended for research and analytical applications. Pamidronate disodium pentahydrate, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium pentahydrate significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium pentahydrate can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma.

For research use only. We do not sell to patients.

Purity: 95%
CAS No.: 109552-15-0
Formula: C₃H₁₉NNa₂O₁₂P₂
Molecular Weight:369.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pamidronate disodium pentahydrate (Standard) Chemical Structure

CAS No.: 109552-15-0

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 109552-15-0
Molecular Weight 369.11
Formula C₃H₁₉NNa₂O₁₂P₂
SMILES

OC(P(O)(O[Na])=O)(CCN)P(O)(O[Na])=O.O.O.O.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Kubalek I, et al. Treatment of reflex sympathetic dystrophy with pamidronate: 29 cases. Rheumatology (Oxford). 2001 Dec;40(12):1394-7. [Content Brief]

[2]. Zarychanski R, et al. Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol. 2006 Jan;81(1):73-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Pamidronate disodium pentahydrate (Standard)

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Pamidronate disodium pentahydrate (Standard)