2,5-Dimethylcelecoxib
Based on 1 Customer Validation
2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin.
For research use only. We do not sell to patients.
- Purity: 99.57%
- CAS No.: 457639-26-8
- Formula: C18H16F3N3O2S
- Molecular Weight:395.40
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Stem Cell Signaling Compound Library
HY-L017
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Wnt/Hedgehog/Notch Compound Library
HY-L020
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Anti-Cancer Compound Library
HY-L025
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HY-L034
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Differentiation Inducing Compound Library
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HY-L060
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Anti-Breast Cancer Compound Library
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Transcription Factor-Targeted Library
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Anti-Liver Cancer Compound Library
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Anti-Colorectal Cancer Compound Library
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Human Metabolite Library
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Anti-Prostate Cancer Compound Library
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Anti-Pulmonary Fibrosis Compound Library
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Cancer Stem Cells Compound Library
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Antihypertensive Compound Library
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Anti-Ovarian Cancer Compound Library
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Mass Spectrometry Human Metabolite Library
HY-L215
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
36 μM
Compound: DMC
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Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTS assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTS assay
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[PMID: 22780961] |
Chemical Information
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CAS No. 457639-26-8
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Appearance Solid
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Molecular Weight 395.40
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Formula C18H16F3N3O2S
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Color White to off-white
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SMILES
O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC(C)=CC=C3C)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (252.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5291 mL | 12.6454 mL | 25.2908 mL | 63.2271 mL |
| 5 mM | 0.5058 mL | 2.5291 mL | 5.0582 mL | 12.6454 mL | |
| 10 mM | 0.2529 mL | 1.2645 mL | 2.5291 mL | 6.3227 mL | |
| 15 mM | 0.1686 mL | 0.8430 mL | 1.6861 mL | 4.2151 mL | |
| 20 mM | 0.1265 mL | 0.6323 mL | 1.2645 mL | 3.1614 mL | |
| 25 mM | 0.1012 mL | 0.5058 mL | 1.0116 mL | 2.5291 mL | |
| 30 mM | 0.0843 mL | 0.4215 mL | 0.8430 mL | 2.1076 mL | |
| 40 mM | 0.0632 mL | 0.3161 mL | 0.6323 mL | 1.5807 mL | |
| 50 mM | 0.0506 mL | 0.2529 mL | 0.5058 mL | 1.2645 mL | |
| 60 mM | 0.0422 mL | 0.2108 mL | 0.4215 mL | 1.0538 mL | |
| 80 mM | 0.0316 mL | 0.1581 mL | 0.3161 mL | 0.7903 mL | |
| 100 mM | 0.0253 mL | 0.1265 mL | 0.2529 mL | 0.6323 mL |
2,5-Dimethylcelecoxib Related Classifications
HY-W010995 Related Classifications
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