457639-26-8
Chemical Structure
2,5-Dimethylcelecoxib
- CAS No.: 457639-26-8
- Formula:C18H16F3N3O2S
- Molecular Weight:395.40
IUPAC Name: 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
InChIKey: NTFOSUUWGCDXEF-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC(C)=CC=C3C)C=C1)(N)=O
Biological Activity: 2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2,5-Dimethylcelecoxib | 99.41% | 2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin. | ||||||||||||||||||||
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2,5-Dimethylcelecoxib-d4 | 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide-d4 is the deuterium labeled 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide. | |||||||||||||||||||||
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-
Similarity Score 0.85
HY-Z76404-Desmethyl-2-methyl celecoxib -
Similarity Score 0.81
HY-Z7639Celecoxib impurity 1 -
Similarity Score 0.80
HY-14398GCelecoxib (GMP) -
Similarity Score 0.77
HY-171992COX-2-IN-55 -
Similarity Score 0.76
HY-121357Lefucoxib -
Similarity Score 0.75
HY-118139Desmethyl Celecoxib -
Similarity Score 0.75
HY-W010983RSC-236 (Standard) -
Similarity Score 0.74
HY-119447RMavacoxib (Standard) -
Similarity Score 0.74
HY-145526Hydroxy celecoxib -
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