Lethedioside A 

Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC₅₀ of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells^[1][2].

Lethedioside A (compound 4) weakly inhibits purified hTCF4/β-catenin complex formation in a cell-free ELISA with an IC₅₀ of 46.9 μM^[1].
Lethedioside A binds directly to GST-Hes1 immobilized on Sepharose beads in a cell-free biochemical binding assay^[1].
Lethedioside A (24 h) potently inhibits LPS (HY-D1056)-induced nitric oxide production in RAW 264.7 macrophages with an IC₅₀ of 7.91 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

622.57

C₂₉H₃₄O₁₅

221289-31-2

O=C1C(C(OC(C2=CC(OC)=C(OC)C=C2)=C1)=CC(OC)=C3)=C3O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO[C@H]5[C@@H]([C@H]([C@H](O)CO5)O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Arai MA, et al. Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells. Chem Sci. 2016;7(2):1514-1520.  [Content Brief]

  [2]. Dong CHEN, et al. Flavanoids from the stems of Aquilaria sinensis. Chinese Journal of Natural Medicines. Volume 10, Issue 4, July 2012, Pages 287-291.