Lethedioside A
Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC50 of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells.
For research use only. We do not sell to patients.
- CAS No.: 221289-31-2
- Formula: C29H34O15
- Molecular Weight:622.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Hes1 9.5 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
>100 μg/mL
Compound: 4
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Cytotoxicity against human KB cells after 72 hrs by neutral red assay
Cytotoxicity against human KB cells after 72 hrs by neutral red assay
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[PMID: 10075750] |
In Vitro
Lethedioside A (compound 4) weakly inhibits purified hTCF4/β-catenin complex formation in a cell-free ELISA with an IC50 of 46.9 μM[1].
Lethedioside A binds directly to GST-Hes1 immobilized on Sepharose beads in a cell-free biochemical binding assay[1].
Lethedioside A (24 h) potently inhibits LPS (HY-D1056)-induced nitric oxide production in RAW 264.7 macrophages with an IC50 of 7.91 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 221289-31-2
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Molecular Weight 622.57
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Formula C29H34O15
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SMILES
O=C1C(C(OC(C2=CC(OC)=C(OC)C=C2)=C1)=CC(OC)=C3)=C3O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO[C@H]5[C@@H]([C@H]([C@H](O)CO5)O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lethedioside A Related Classifications
HY-N3393 Related Classifications
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