221289-31-2
Chemical Structure
Lethedioside A
- CAS No.: 221289-31-2
- Formula:C29H34O15
- Molecular Weight:622.57
IUPAC Name: 2-(3,4-dimethoxyphenyl)-7-methoxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChIKey: OQEZCWWFGXYLQY-YUYUGGDUSA-N
SMILES: O=C1C(C(OC(C2=CC(OC)=C(OC)C=C2)=C1)=CC(OC)=C3)=C3O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO[C@H]5[C@@H]([C@H]([C@H](O)CO5)O)O
Biological Activity: Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC50 of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells[1][2].
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Lethedioside A | Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC50 of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells. | |||||||||||||||||||||
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References
- [1]. Arai MA, et al. Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells. Chem Sci. 2016;7(2):1514-1520. [Content Brief]
- [2]. Dong CHEN, et al. Flavanoids from the stems of Aquilaria sinensis. Chinese Journal of Natural Medicines. Volume 10, Issue 4, July 2012, Pages 287-291.
