1. Stem Cell/Wnt
  2. Wnt
  3. KY-02327

KY-02327 

Cat. No.: HY-124156
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KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation.

For research use only. We do not sell to patients.

KY-02327 Chemical Structure

KY-02327 Chemical Structure

CAS No. : 2093407-25-9

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Description

KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation[1].

In Vitro

KY-02327 (1-10 μM; 2 days; MC3T3E1 cells, a murine pre-osteoblast cell line) increases β-catenin protein level together with Runx2 and accumulated nuclear β-catenin in a dose-dependent manner[1].
KY-02327 (1-10 μM) increases the mRNA levels of osteoblast differentiation markers collagen 1a (Col1a) and osteocalcin (OCN)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KY-02327 (20 mg/kg; p.o.; 5 sequential days per week for 4 weeks) successfully rescues bone loss in the ovariectomized (OVX) mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old female BL6 mice (ovariectomized (OVX)-induced osteoporosis model mice)[1]
Dosage: 20 mg/kg
Administration: P.o.; administered for 5 sequential days per week for 4 weeks
Result: Newly formed bones which labeled with calcein were decreased in the femur of vehicle‐treated OVX mice.
Molecular Weight

373.45

Formula

C₂₀H₂₇N₃O₄

CAS No.
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KY-02327
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