2. Stem Cell/Wnt Epigenetics
  3. Wnt β-catenin Histone Acetyltransferase
  4. Windorphen

Windorphen is a Wnt/β-catenin signal inhibitor that specifically targets the function of the c-terminal transactivation domain of β-catenin-1 but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP.

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Windorphen Chemical Structure

Windorphen Chemical Structure

CAS No. : 19881-70-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 130 In-stock
Solution
10 mM * 1 mL in DMSO USD 130 In-stock
Solid
2 mg USD 78 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Windorphen is a Wnt/β-catenin signal inhibitor that specifically targets the function of the c-terminal transactivation domain of β-catenin-1 but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP[1].

Molecular Weight

302.75

Formula

C17H15ClO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C/C(C1=CC=C(OC)C=C1)=C(Cl)/C2=CC=C(OC)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (206.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3031 mL 16.5153 mL 33.0306 mL
5 mM 0.6606 mL 3.3031 mL 6.6061 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥96.0%

COA (252 KB) HNMR (231 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3031 mL 16.5153 mL 33.0306 mL 82.5764 mL
5 mM 0.6606 mL 3.3031 mL 6.6061 mL 16.5153 mL
10 mM 0.3303 mL 1.6515 mL 3.3031 mL 8.2576 mL
15 mM 0.2202 mL 1.1010 mL 2.2020 mL 5.5051 mL
20 mM 0.1652 mL 0.8258 mL 1.6515 mL 4.1288 mL
25 mM 0.1321 mL 0.6606 mL 1.3212 mL 3.3031 mL
30 mM 0.1101 mL 0.5505 mL 1.1010 mL 2.7525 mL
40 mM 0.0826 mL 0.4129 mL 0.8258 mL 2.0644 mL
50 mM 0.0661 mL 0.3303 mL 0.6606 mL 1.6515 mL
60 mM 0.0551 mL 0.2753 mL 0.5505 mL 1.3763 mL
80 mM 0.0413 mL 0.2064 mL 0.4129 mL 1.0322 mL
100 mM 0.0330 mL 0.1652 mL 0.3303 mL 0.8258 mL
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Windorphen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Windorphen19881-70-0Wntβ-cateninHistone AcetyltransferaseBeta cateninHATsHATWnt/β-catenin signal inhibitorβ-catenin-1p300Inhibitorinhibitorinhibit

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