1. Anti-infection PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis
  2. Antibiotic Bacterial Akt GSK-3 β-catenin c-Myc
  3. Chrysomycin A

Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway.

For research use only. We do not sell to patients.

Chrysomycin A Chemical Structure

Chrysomycin A Chemical Structure

CAS No. : 82196-88-1

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250 μg USD 324 In-stock

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Based on 1 publication(s) in Google Scholar

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Description

Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway[1].

In Vitro

Chrysomycin A (0.2-1.8 μM; 48 h) has anti-glioblastoma efficacy, and inhibits cell viability in U251 and U87-MG human glioblastoma, as well as migration and invasion[1].
Chrysomycin A (0.2-1.8 μM; 48 h) inhibits Akt/GSK-3β/β-Catenin signaling pathway in U251 and U87-MG cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U251 and U87-MG human glioblastoma
Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
Incubation Time: 48 hours
Result: Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively.

Western Blot Analysis[1]

Cell Line: U251 and U87-MG human glioblastoma
Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG
Incubation Time: 48 hours
Result: Significantly downregulated the expression of slug and MMP2.
Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1.
Molecular Weight

508.52

Formula

C28H28O9

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(C=C)=CC(OC)=C2C3=CC(OC)=C4C(O)=CC=C([C@H]5[C@@H]([C@]([C@H]([C@@H](C)O5)O)(C)O)O)C4=C3O1

Initial Source

marine-derived strain Streptomyces sp. 891

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Chrysomycin A
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HY-126771
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