1. Stem Cell/Wnt
  2. β-catenin

NRX-252262 

Cat. No.: HY-111760
Handling Instructions

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.

For research use only. We do not sell to patients.

NRX-252262 Chemical Structure

NRX-252262 Chemical Structure

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].

IC50 & Target

EC50: 3.8 nM (β-Catenin-SCFβ-TrCP)[1]

In Vitro

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells[1].

References
Molecular Weight

545.36

Formula

C₂₃H₁₇Cl₂F₃N₂O₄S

SMILES

O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
NRX-252262
Cat. No.:
HY-111760
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NRX-252262

Cat. No.: HY-111760