1. Stem Cell/Wnt
  2. β-catenin
  3. NRX-252262

NRX-252262 

Cat. No.: HY-111760 Purity: 98.97%
Handling Instructions

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.

For research use only. We do not sell to patients.

NRX-252262 Chemical Structure

NRX-252262 Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].

IC50 & Target

EC50: 3.8 nM (β-Catenin-SCFβ-TrCP)[1]

In Vitro

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells[1].

Molecular Weight

545.36

Formula

C₂₃H₁₇Cl₂F₃N₂O₄S

SMILES

O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8337 mL 9.1683 mL 18.3365 mL
5 mM 0.3667 mL 1.8337 mL 3.6673 mL
10 mM 0.1834 mL 0.9168 mL 1.8337 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NRX-252262NRX252262NRX 252262β-cateninBeta cateninInhibitorinhibitorinhibit

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Product Name:
NRX-252262
Cat. No.:
HY-111760
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