2438637-61-5
2438637-61-5
Chemical Structure
NRX-252262
- CAS No.: 2438637-61-5
- Formula:C23H17Cl2F3N2O4S
- Molecular Weight:545.36
IUPAC Name: 4-((2,6-dichlorophenyl)thio)-3-(5,6-dimethoxyisoindoline-2-carbonyl)-6-(trifluoromethyl)pyridin-2(1H)-one
InChIKey: SPAYLOCXFWJEBL-UHFFFAOYSA-N
SMILES: O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
Biological Activity: NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].
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NRX-252262 | 99.57% | NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM. | ||||||||||||||||||||
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References
Keywords
