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Cat. No.: HY-111760R

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NRX-252262 (Standard)

NRX-252262 (Standard) is the analytical standard of NRX-252262 (HY-111760). This product is intended for research and analytical applications. NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC₅₀ of 3.8 nM.

For research use only. We do not sell to patients.

CAS No.: 2438637-61-5
Formula: C₂₃H₁₇Cl₂F₃N₂O₄S
Molecular Weight:545.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NRX-252262 (Standard) Chemical Structure

CAS No.: 2438637-61-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2438637-61-5
Molecular Weight 545.36
Formula C₂₃H₁₇Cl₂F₃N₂O₄S
SMILES

O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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