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Cat. No.: HY-133093

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Murayaquinone

(Synonyms: PKF118-774)

Murayaquinone (PKF118-774) is a β-catenin/Tcf4 complex inhibitor with an IC₅₀ of 2.4 μM. Murayaquinone is a nematicidal agent found in Streptomyces sp. AN140557.

For research use only. We do not sell to patients.

CAS No.: 100843-91-2
Formula: C₁₉H₁₆O₅
Molecular Weight:324.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Murayaquinone Chemical Structure

CAS No.: 100843-91-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Murayaquinone (PKF118-774) is a β-catenin/Tcf4 complex inhibitor with an IC₅₀ of 2.4 μM. Murayaquinone is a nematicidal agent found in Streptomyces sp. AN140557^[1]^[2].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.78 μM Compound: 85; PKF118-744	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTS assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTS assay	[PMID: 33445154]

In Vitro

Murayaquinone shows an IC₅₀ of 2.4 μM for β-catenin/Tcf4 complex[1].
Murayaquinone (3.12-25 μM; 24 h) shows significant dose-dependent nematicidal activity and egg-hatching inhibition^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

nematodes and nematodes eggs
Concentration:

3.12, 6.25, 12.5, and 25 μM
Incubation Time:

24 h
Result:

Showed significant dose-dependent nematicidal activity and egg-hatching inhibition.

Chemical Information

CAS No. 100843-91-2
Molecular Weight 324.33
Formula C₁₉H₁₆O₅
SMILES

O=C1C(=O)C2=C(O)C(=C(C=C2C=3C=CC=C(O)C13)C(=O)CCC)C
Synonyms

PKF118-774
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kang M K, et al. Discovery of murayaquinone from an endophytic bacterium Streptomyces sp. AN140557 as a potent inhibitor of the pine wood nematode, Bursaphelenchus xylophilus[J]. Pest Management Science, 2026, 82(2): 1765-1775.

[2]. Radwan AA, et al. Target β-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1664-70. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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