100843-91-2
100843-91-2
Chemical Structure
Murayaquinone
Synonym(s): PKF118-774
- CAS No.: 100843-91-2
- Formula:C19H16O5
- Molecular Weight:324.33
IUPAC Name: 3-butyryl-1,8-dihydroxy-2-methylphenanthrene-9,10-dione
InChIKey: YJQYHFMKGAVKDP-UHFFFAOYSA-N
SMILES: O=C1C(=O)C2=C(O)C(=C(C=C2C=3C=CC=C(O)C13)C(=O)CCC)C
Biological Activity: Murayaquinone (PKF118-774) is a β-catenin/Tcf4 complex inhibitor with an IC50 of 2.4 μM. Murayaquinone is a nematicidal agent found in Streptomyces sp. AN140557[1][2].
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Murayaquinone | Murayaquinone (PKF118-774) is a β-catenin/Tcf4 complex inhibitor with an IC50 of 2.4 μM. Murayaquinone is a nematicidal agent found in Streptomyces sp. AN140557. | |||||||||||||||||||||
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References
- [1]. Kang M K, et al. Discovery of murayaquinone from an endophytic bacterium Streptomyces sp. AN140557 as a potent inhibitor of the pine wood nematode, Bursaphelenchus xylophilus[J]. Pest Management Science, 2026, 82(2): 1765-1775.
- [2]. Radwan AA, et al. Target β-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1664-70. [Content Brief]
Keywords
