country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-111460

Copy Link Print Information

15-Oxospiramilactone

(Synonyms: NC 043)

Customer Review

Based on 1 Customer Validation

15-Oxospiramilactone is a diterpene derivative. 15-Oxospiramilactone can inhibit Wnt/β-catenin signaling and tumorigenesis of colon cancer cells.

For research use only. We do not sell to patients.

Purity: 98.96%
CAS No.: 1053172-87-4
Formula: C₂₀H₂₆O₄
Molecular Weight:330.42

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

15-Oxospiramilactone Chemical Structure

CAS No.: 1053172-87-4

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

15-Oxospiramilactone is a diterpene derivative. 15-Oxospiramilactone can inhibit Wnt/β-catenin signaling and tumorigenesis of colon cancer cells^[1].

All Wnt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.22 μM Compound: S-3	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 24684844]
HL-60	IC₅₀	6.36 μM Compound: S-3	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 24684844]
MCF7	IC₅₀	3.25 μM Compound: S-3	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 24684844]
MEF	IC₅₀	1.736 μM Compound: S-3	Induction of apoptosis in Bax(-/-)/Bak(-/-) MEF after 48 hrs Induction of apoptosis in Bax(-/-)/Bak(-/-) MEF after 48 hrs	[PMID: 24684844]
SMMC-7721	IC₅₀	3.96 μM Compound: S-3	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 24684844]
SW480	IC₅₀	1.7 μM Compound: 62; NCO43	Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 33445154]
SW480	IC₅₀	3.58 μM Compound: S-3	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 24684844]

Chemical Information

CAS No. 1053172-87-4
Appearance Solid
Molecular Weight 330.42
Formula C₂₀H₂₆O₄
Color White to off-white
SMILES

O=C1[C@]23[C@@]4([H])[C@@]5(C(C([C@](CC5)([H])C4)=C)=O)[C@H](O)C[C@]2([H])[C@@](C)(CCC3)CO1
Synonyms

NC 043
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang W, et al. A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res. 2011 May;21(5):730-40. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

15-Oxospiramilactone

All Wnt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

15-Oxospiramilactone Related Classifications

HY-111460 Related Classifications