1. Stem Cell/Wnt
  2. β-catenin
  3. NRX-2663

NRX-2663 

Cat. No.: HY-141448
Handling Instructions

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM.

For research use only. We do not sell to patients.

NRX-2663 Chemical Structure

NRX-2663 Chemical Structure

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Description

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM[1].

IC50 & Target

EC50: 22.9 µM (β-catenin:β-TrCP Interaction)[1]
Kd: 54.8 nM (β-catenin:β-TrCP Interaction)[1]

In Vitro

NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC50 of 80 µM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

418.32

Formula

C₂₀H₁₃F₃N₂O₅

SMILES

OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)OC3=CC=CC=C3)=O)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NRX-2663NRX2663NRX 2663β-cateninBeta cateninE3ligasedegradationmutantSCFβ-TrCPPPISer33Ser37Inhibitorinhibitorinhibit

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Product Name:
NRX-2663
Cat. No.:
HY-141448
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