Cat. No.: HY-141448

NRX-2663

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCF^β-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC₅₀ of 22.9 μM and a K_d of 54.8 nM.

For research use only. We do not sell to patients.

Purity: 98.96%
CAS No.: 2763260-34-8
Formula: C₂₀H₁₃F₃N₂O₅
Molecular Weight:418.32

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

NRX-2663 Chemical Structure

CAS No.: 2763260-34-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

EC50: 22.9 µM (β-catenin:β-TrCP Interaction)^[1]
Kd: 54.8 nM (β-catenin:β-TrCP Interaction)^[1]

In Vitro

NRX-2663 displays both improved potency in the binding assay with pSer33/Ser37 β-catenin (EC₅₀ of 80 μM) and cooperativity of binding (13-fold). NRX-2663 also markedly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, with ubiquitin chain formation at ligand concentrations of 16 μM and above resembling ubiquitin chain formation on wild-type pSer33/pSer37 β-catenin peptide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2763260-34-8
Appearance Solid
Molecular Weight 418.32
Formula C₂₀H₁₃F₃N₂O₅
Color White to light yellow
SMILES

OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)OC3=CC=CC=C3)=O)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Phytomedicine

Karanjin counteracts OVX-induced bone loss by dual regulating bone remodeling. [Abstract]

2025 Oct:146:157099. PMID: 40774011

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (239.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3905 mL

11.9526 mL

23.9051 mL

5 mM

0.4781 mL

2.3905 mL

4.7810 mL

10 mM

0.2391 mL

1.1953 mL

2.3905 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3905 mL	11.9526 mL	23.9051 mL	59.7629 mL
	5 mM	0.4781 mL	2.3905 mL	4.7810 mL	11.9526 mL
	10 mM	0.2391 mL	1.1953 mL	2.3905 mL	5.9763 mL
	15 mM	0.1594 mL	0.7968 mL	1.5937 mL	3.9842 mL
	20 mM	0.1195 mL	0.5976 mL	1.1953 mL	2.9881 mL
	25 mM	0.0956 mL	0.4781 mL	0.9562 mL	2.3905 mL
	30 mM	0.0797 mL	0.3984 mL	0.7968 mL	1.9921 mL
	40 mM	0.0598 mL	0.2988 mL	0.5976 mL	1.4941 mL
	50 mM	0.0478 mL	0.2391 mL	0.4781 mL	1.1953 mL
	60 mM	0.0398 mL	0.1992 mL	0.3984 mL	0.9960 mL
	80 mM	0.0299 mL	0.1494 mL	0.2988 mL	0.7470 mL
	100 mM	0.0239 mL	0.1195 mL	0.2391 mL	0.5976 mL

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NRX-2663

Metabolism/Protease Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Ubiquitination Compound Library

Cytoskeleton Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Protein-protein Interaction Inhibitor Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Antihypertensive Compound Library

Metabolic Enzyme Compound Library

Extracellular Vesicles (EVs) Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Amino Acid Metabolism Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) NRX-2663

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

NRX-2663 Related Classifications

Cat. No.: HY-141448