NLS-StAx-h
Based on 1 publication(s) in Google Scholar
NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells.
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- CAS. Nr.: 2872559-21-0
- Formel: C161H275N55O29
- Molecular Weight:3445.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) NLS-StAx-h
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Biologische Aktivität
IC50: 1.4 μM (Wnt)[1]
NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells[1].
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW-480 and DLD-1 cells
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Concentration:10 μM
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Incubation Time:72 hr
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Result:Reduced the viability of both SW-480 and DLD-1 by more than 80%.
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Cell Line:DLD-1 cells
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Concentration:5 and 10 μM
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Incubation Time:24 hr
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Result:Resulted in dose-dependent inhibition of wound closure (wound closure: 52% at 5 μM, and 24% at 10 μM).
Chemical Information
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CAS. Nr. 2872559-21-0
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Molecular Weight 3445.25
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Formel C161H275N55O29
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Exp Cell Res
Ketohexokinase-A deficiency attenuates the proliferation via reducing β-catenin in gastric cancer cells. [Abstract]2024 Apr 16;438(1):114038. PMID: 38614422
Reinheit & Dokumentation
Verweise
[1]. Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions [Content Brief]
[2]. ang Z, et al. Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives. Med Res Rev. 2021 Jul;41(4):2109-2129. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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