1. Stem Cell/Wnt
  2. Wnt β-catenin
  3. NLS-StAx-h

NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells.

For research use only. We do not sell to patients.

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NLS-StAx-h Chemical Structure

NLS-StAx-h Chemical Structure

CAS No. : 2872559-21-0

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Description

NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells[1][2].

IC50 & Target

IC50: 1.4 μM (Wnt)[1]

In Vitro

NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells[1].
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SW-480 and DLD-1 cells
Concentration: 10 μM
Incubation Time: 72 hr
Result: Reduced the viability of both SW-480 and DLD-1 by more than 80%.

Cell Migration Assay [1]

Cell Line: DLD-1 cells
Concentration: 5 and 10 μM
Incubation Time: 24 hr
Result: Resulted in dose-dependent inhibition of wound closure (wound closure: 52% at 5 μM, and 24% at 10 μM).
Molecular Weight

3445.25

Formula

C161H275N55O29

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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NLS-StAx-h Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NLS-StAx-h
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HY-P2272
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