NLS-StAx-h
Based on 1 publication(s) in Google Scholar
NLS-StAx-h is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 2872559-21-0
- Formula: C161H275N55O29
- Molecular Weight:3445.25
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NLS-StAx-h
More
Biological Activity
IC50: 1.4 μM (Wnt)[1]
NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells[1].
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:SW-480 and DLD-1 cells
-
Concentration:10 μM
-
Incubation Time:72 hr
-
Result:Reduced the viability of both SW-480 and DLD-1 by more than 80%.
-
Cell Line:DLD-1 cells
-
Concentration:5 and 10 μM
-
Incubation Time:24 hr
-
Result:Resulted in dose-dependent inhibition of wound closure (wound closure: 52% at 5 μM, and 24% at 10 μM).
Chemical Information
-
CAS No. 2872559-21-0
-
Molecular Weight 3445.25
-
Formula C161H275N55O29
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Exp Cell Res
Ketohexokinase-A deficiency attenuates the proliferation via reducing β-catenin in gastric cancer cells. [Abstract]2024 Apr 16;438(1):114038. PMID: 38614422
Purity & Documentation
References
[1]. Laura Dietrich, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions [Content Brief]
[2]. ang Z, et al. Direct targeting of β-catenin in the Wnt signaling pathway: Current progress and perspectives. Med Res Rev. 2021 Jul;41(4):2109-2129. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLS-StAx-h Related Classifications
HY-P2272 Related Classifications
Powered by Bioz