1. Stem Cell/Wnt
  2. β-catenin
    Wnt
  3. UU-T02

UU-T02 

Cat. No.: HY-117233
Handling Instructions

UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells.

For research use only. We do not sell to patients.

UU-T02 Chemical Structure

UU-T02 Chemical Structure

CAS No. : 1500080-17-0

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Description

UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].

IC50 & Target

Ki: 1.36 μM (β-catenin/Tcf PPI)[1].
IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)[2].

In Vitro

UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[2].
UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM,respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

665.09

Formula

C₃₃H₃₃ClN₄O₉

CAS No.
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UU-T02
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