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Cat. No.: HY-182632

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LP-935001

LP-935001 is a Notum carboxylesterase inhibitor with an IC₅₀ of 0.4 nM.LP-935001 prevents palmitoleate group removal from Wnt proteins, restores Wnt/β-catenin signaling.LP-935001 enhances cortical bone thickness in rodent models.LP-935001 can be used for the research of bone loss/nonvertebral fractures.

For research use only. We do not sell to patients.

CAS No.: 1875037-24-3
Formula: C₁₃H₈ClFO₂S
Molecular Weight:282.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LP-935001 Chemical Structure

CAS No.: 1875037-24-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

All Carboxylesterase (CES) Isoforms :

All Wnt Isoforms :

In Vitro

LP-935001 potently inhibits human Notum carboxylesterase activity in a cell-free biochemical assay with an IC₅₀ of 0.4 nM^[1].
LP-935001 restores Wnt/β-catenin signaling in a cell-based reporter assay in the presence of Notum with an EC₅₀ of 12 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1875037-24-3
Molecular Weight 282.72
Formula C₁₃H₈ClFO₂S
SMILES

O=C(C1=CC2=C(C3=C(CC2)C(Cl)=CC(F)=C3)S1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bayle ED, et al. Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. J Med Chem. 2021;64(8):4289-4311. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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LP-935001

All Carboxylesterase (CES) Isoforms

All Wnt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LP-935001 Related Classifications

HY-182632 Related Classifications