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Cat. No.: HY-182632

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LP-935001

LP-935001 is a Notum carboxylesterase inhibitor with an IC₅₀ of 0.4 nM.LP-935001 prevents palmitoleate group removal from Wnt proteins, restores Wnt/β-catenin signaling.LP-935001 enhances cortical bone thickness in rodent models.LP-935001 can be used for the research of bone loss/nonvertebral fractures.

For research use only. We do not sell to patients.

CAS No.: 1875037-24-3
Formula: C₁₃H₈ClFO₂S
Molecular Weight:282.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LP-935001 Chemical Structure

CAS No.: 1875037-24-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Carboxylesterase (CES) Isoforms :

All Wnt Isoforms :

In Vitro

LP-935001 potently inhibits human Notum carboxylesterase activity in a cell-free biochemical assay with an IC₅₀ of 0.4 nM^[1].
LP-935001 restores Wnt/β-catenin signaling in a cell-based reporter assay in the presence of Notum with an EC₅₀ of 12 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1875037-24-3
Molecular Weight 282.72
Formula C₁₃H₈ClFO₂S
SMILES

O=C(C1=CC2=C(C3=C(CC2)C(Cl)=CC(F)=C3)S1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bayle ED, et al. Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. J Med Chem. 2021;64(8):4289-4311. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Protocols
Purity & Documentation
References

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LP-935001

All Carboxylesterase (CES) Isoforms

All Wnt Isoforms