1. Stem Cell/Wnt
  2. Wnt
  3. Fz7-21 TFA

Fz7-21 TFA (Synonyms: Ac-LPSDDLEFWCHVMY-NH2 TFA)

Cat. No.: HY-P1454A Purity: 99.87%
Handling Instructions

Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA , a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fz7-21 TFA Chemical Structure

Fz7-21 TFA Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 1156 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA , a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1].

IC50 & Target

EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)[1]

Molecular Weight

1910.07

Formula

C₈₅H₁₁₅N₁₈F₃O₂₅S₂

Sequence

Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2

Sequence Shortening

Ac-LPSDDLEFWCHVMY-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (17.45 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5235 mL 2.6177 mL 5.2354 mL
5 mM 0.1047 mL 0.5235 mL 1.0471 mL
10 mM 0.0524 mL 0.2618 mL 0.5235 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (1.31 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Fz7-21Ac-LPSDDLEFWCHVMY-NH2WntpeptideCRDβ-cateninWNT3AWNT1subclassselective intestinalstemcellsInhibitorinhibitorinhibit

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Fz7-21 TFA
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HY-P1454A
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