1. Stem Cell/Wnt
  2. Wnt
  3. Fz7-21

Fz7-21 (Synonyms: (Ac)-LPSDDLEFWCHVMY-NH2)

Cat. No.: HY-P1454
Handling Instructions

Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).

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Fz7-21 Chemical Structure

Fz7-21 Chemical Structure

CAS No. : 2247635-23-8

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Description

Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1].

IC50 & Target

EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)[1]

Molecular Weight

1796.05

Formula

C₈₃H₁₁₄N₁₈O₂₃S₂

CAS No.

2247635-23-8

Sequence

(Ac)-{Leu}{Pro}{Ser}{Asp}{Asp}{Leu}{Glu}{Phe}{Trp}{Cys}{His}{Val}{Met}{Tyr}-NH2

Sequence Shortening

(Ac)-LPSDDLEFWCHVMY-NH2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Fz7-21(Ac)-LPSDDLEFWCHVMY-NH2WntpeptideCRDβ-cateninWNT3AWNT1subclassselective intestinalstemcellsInhibitorinhibitorinhibit

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Fz7-21
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HY-P1454
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