1. Stem Cell/Wnt
  2. β-catenin
  3. NRX-103095

NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM.

For research use only. We do not sell to patients.

NRX-103095 Chemical Structure

NRX-103095 Chemical Structure

CAS No. : 2763260-38-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 758 In-stock
Solution
10 mM * 1 mL in DMSO USD 758 In-stock
Solid
5 mg USD 650 In-stock
10 mg USD 1050 In-stock
25 mg USD 2050 In-stock
50 mg USD 3300 In-stock
100 mg USD 5350 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM[1].

IC50 & Target

EC50: 163 nM (β-catenin:β-TrCP Interaction)[1]

Molecular Weight

530.35

Formula

C22H16Cl2F3N3O3S

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)=O)=C1)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (188.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8855 mL 9.4277 mL 18.8555 mL
5 mM 0.3771 mL 1.8855 mL 3.7711 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8855 mL 9.4277 mL 18.8555 mL 47.1387 mL
5 mM 0.3771 mL 1.8855 mL 3.7711 mL 9.4277 mL
10 mM 0.1886 mL 0.9428 mL 1.8855 mL 4.7139 mL
15 mM 0.1257 mL 0.6285 mL 1.2570 mL 3.1426 mL
20 mM 0.0943 mL 0.4714 mL 0.9428 mL 2.3569 mL
25 mM 0.0754 mL 0.3771 mL 0.7542 mL 1.8855 mL
30 mM 0.0629 mL 0.3143 mL 0.6285 mL 1.5713 mL
40 mM 0.0471 mL 0.2357 mL 0.4714 mL 1.1785 mL
50 mM 0.0377 mL 0.1886 mL 0.3771 mL 0.9428 mL
60 mM 0.0314 mL 0.1571 mL 0.3143 mL 0.7856 mL
80 mM 0.0236 mL 0.1178 mL 0.2357 mL 0.5892 mL
100 mM 0.0189 mL 0.0943 mL 0.1886 mL 0.4714 mL
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NRX-103095 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NRX-103095
Cat. No.:
HY-141450
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