1. Stem Cell/Wnt
  2. β-catenin
  3. NRX-103095

NRX-103095 

Cat. No.: HY-141450
Handling Instructions

NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM.

For research use only. We do not sell to patients.

NRX-103095 Chemical Structure

NRX-103095 Chemical Structure

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Description

NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM[1].

IC50 & Target

EC50: 163 nM (β-catenin:β-TrCP Interaction)[1]

Molecular Weight

530.35

Formula

C₂₂H₁₆Cl₂F₃N₃O₃S

SMILES

O=C(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)=O)=C1)N(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NRX-103095NRX103095NRX 103095β-cateninBeta cateninE3ligasemutantSCFβ-TrCPPPISer33Ser37Inhibitorinhibitorinhibit

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NRX-103095
Cat. No.:
HY-141450
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