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Cat. No.: HY-129694

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Lenoremycin

(Synonyms: Ro 21-6150; Antibiotic A-130-A)

Lenoremycin (Ro 21-6150) is a microbial metabolite. Lenoremycin decreases β-catenin and cyclin D1 proteins levels. Lenoremycin decreases cancer stem cells (CSCs) populations via inducing reactive oxygen species production.

For research use only. We do not sell to patients.

CAS No.: 51257-84-2
Formula: C₄₇H₇₈O₁₃
Molecular Weight:851.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Lenoremycin Chemical Structure

CAS No.: 51257-84-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.2 μM Compound: 9	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by resazurin assay Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by resazurin assay	[PMID: 28029795]
HEK293	EC₅₀	38 nM Compound: 9	Modulation of unfolded protein response in tunicamycin-treated HEK293 cells after 48 hrs by ASGR-Cluc secretion assay Modulation of unfolded protein response in tunicamycin-treated HEK293 cells after 48 hrs by ASGR-Cluc secretion assay	[PMID: 28029795]

Chemical Information

CAS No. 51257-84-2
Molecular Weight 851.11
Formula C₄₇H₇₈O₁₃
SMILES

C[C@H]1[C@]2(O[C@](C[C@H]1O[C@@H]3O[C@@H]([C@H](CC3)OC)C)([H])[C@@H](C)/C=C(C)/C([C@H](C)C[C@H](C)C(O)=O)=O)O[C@@](CC2)([C@]4([H])O[C@@]5([C@@H](CC4)C)O[C@]([C@@]6([H])O[C@](O)([C@@H](C[C@@H]6C)C)CO)([H])C[C@@H]5C)C
Synonyms

Ro 21-6150; Antibiotic A-130-A
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces hygroscopicus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ikeda H, et al. Identification of the polyether ionophore lenoremycin through a new screening strategy for targeting cancer stem cells. J Antibiot (Tokyo). 2022 Dec;75(12):671-678. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Lenoremycin

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Lenoremycin Related Classifications

HY-129694 Related Classifications