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Cat. No.: HY-115474

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Cardionogen-2

Cardionogen-2 is a biphasic modulator of cardiogenesis, either promoting or inhibiting heart formation depending on the stage of treatment. Cardionogen-2 inhibits Wnt/β-catenin-dependent transcription in murine embryonic stem (ES) cells and zebrafish embryos.

For research use only. We do not sell to patients.

CAS No.: 578755-52-9
Formula: C₁₆H₁₃N₅O₂S
Molecular Weight:339.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Cardionogen-2 Chemical Structure

CAS No.: 578755-52-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

All Wnt Isoforms :

In Vitro

In zebrafish embryos and murine embryonic stem (ES) cells, Cardionogen-2 treatment promotes cardiogenesis during and after gastrulation, whereas it inhibits heart formation before gastrulation. Cardionogen-2-induced effects can be antagonized by increasing Wnt/β-catenin signaling activity. Cardionogen-2 inhibits Wnt/β-catenin-dependent transcription in murine ES cells and zebrafish embryos^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 578755-52-9
Molecular Weight 339.37
Formula C₁₆H₁₃N₅O₂S
SMILES

COC(C=CC(C1=NN2C(C3=CC=CC=N3)=NN=C2S1)=C4)=C4OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ni TT, et al. Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol. 2011 Dec 23;18(12):1658-68. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cardionogen-2

All Wnt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cardionogen-2 Related Classifications

HY-115474 Related Classifications